BRD-K40255344_EI-215_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

268 genes differentially expressed following the BRD-K40255344_EI-215_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACBD3 acyl-CoA binding domain containing 3
ALOX5 arachidonate 5-lipoxygenase
ARF1 ADP-ribosylation factor 1
ARF4 ADP-ribosylation factor 4
ARMCX3 armadillo repeat containing, X-linked 3
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BAD BCL2-associated agonist of cell death
BHLHE41 basic helix-loop-helix family, member e41
BLVRB biliverdin reductase B
BUD31 BUD31 homolog (S. cerevisiae)
CANX calnexin
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLDN3 claudin 3
CLEC7A C-type lectin domain family 7, member A
CTH cystathionine gamma-lyase
CTSL cathepsin L
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DIABLO diablo, IAP-binding mitochondrial protein
DMBT1 deleted in malignant brain tumors 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYD dihydropyrimidine dehydrogenase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GOLT1B golgi transport 1B
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GSR glutathione reductase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IFT20 intraflagellar transport 20
IL1RN interleukin 1 receptor antagonist
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LY75 lymphocyte antigen 75
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCUR1 mitochondrial calcium uniporter regulator 1
MED8 mediator complex subunit 8
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
NAMPT nicotinamide phosphoribosyltransferase
NANS N-acetylneuraminic acid synthase
NARS asparaginyl-tRNA synthetase
NLGN4X neuroligin 4, X-linked
NPC1 Niemann-Pick disease, type C1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRBF2 nuclear receptor binding factor 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHGDH phosphoglycerate dehydrogenase
PIGA phosphatidylinositol glycan anchor biosynthesis, class A
PITX1 paired-like homeodomain 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSIP1 PC4 and SFRS1 interacting protein 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTS 6-pyruvoyltetrahydropterin synthase
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB5A RAB5A, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RB1 retinoblastoma 1
RBM47 RNA binding motif protein 47
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RECQL RecQ helicase-like
RFC2 replication factor C (activator 1) 2, 40kDa
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SERP1 stress-associated endoplasmic reticulum protein 1
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPINK1 serine peptidase inhibitor, Kazal type 1
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TARS threonyl-tRNA synthetase
TBL2 transducin (beta)-like 2
TCEA1 transcription elongation factor A (SII), 1
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM41B transmembrane protein 41B
TMPRSS3 transmembrane protease, serine 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TP53BP2 tumor protein p53 binding protein 2
TREM1 triggering receptor expressed on myeloid cells 1
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TWIST1 twist family bHLH transcription factor 1
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UPP1 uridine phosphorylase 1
UQCRH ubiquinol-cytochrome c reductase hinge protein
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZFAND5 zinc finger, AN1-type domain 5

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AMOTL2 angiomotin like 2
ANKRD10 ankyrin repeat domain 10
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCHE butyrylcholinesterase
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CCR2 chemokine (C-C motif) receptor 2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CHRDL1 chordin-like 1
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CNN3 calponin 3, acidic
COL18A1 collagen, type XVIII, alpha 1
COL4A5 collagen, type IV, alpha 5
COL4A6 collagen, type IV, alpha 6
CPB1 carboxypeptidase B1 (tissue)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCN decorin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENG endoglin
EPB41L2 erythrocyte membrane protein band 4.1-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HOXB2 homeobox B2
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KLK5 kallikrein-related peptidase 5
KRT6B keratin 6B, type II
LAMB1 laminin, beta 1
LDOC1 leucine zipper, down-regulated in cancer 1
LOXL1 lysyl oxidase-like 1
LUM lumican
MAN1C1 mannosidase, alpha, class 1C, member 1
MAP7 microtubule-associated protein 7
MEF2C myocyte enhancer factor 2C
MGLL monoglyceride lipase
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1E metallothionein 1E
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFASC neurofascin
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPR3 natriuretic peptide receptor 3
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NYNRIN NYN domain and retroviral integrase containing
PALLD palladin, cytoskeletal associated protein
PBX1 pre-B-cell leukemia homeobox 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PON2 paraoxonase 2
PRSS23 protease, serine, 23
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRM2 ribonucleotide reductase M2
S100A4 S100 calcium binding protein A4
SFRP1 secreted frizzled-related protein 1
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMTN smoothelin
SPRY4 sprouty homolog 4 (Drosophila)
SSFA2 sperm specific antigen 2
STMN1 stathmin 1
TARP TCR gamma alternate reading frame protein
TCF4 transcription factor 4
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM109 transmembrane protein 109
TNC tenascin C
TPM1 tropomyosin 1 (alpha)
TRAM2 translocation associated membrane protein 2
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
VCAN versican
VCL vinculin
VTCN1 V-set domain containing T cell activation inhibitor 1
WSCD1 WSC domain containing 1
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
Funding