BRD-K40373196_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K40373196_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AKR1C2 aldo-keto reductase family 1, member C2
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BTG2 BTG family, member 2
C6ORF62 chromosome 6 open reading frame 62
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CXCL2 chemokine (C-X-C motif) ligand 2
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA1598
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
MAOB monoamine oxidase B
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
SOD2 superoxide dismutase 2, mitochondrial
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
C14ORF169 chromosome 14 open reading frame 169
CCND1 cyclin D1
CCNF cyclin F
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ERLIN1 ER lipid raft associated 1
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
NID1 nidogen 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PNMA1 paraneoplastic Ma antigen 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TMEM2 transmembrane protein 2
TNS3 tensin 3
TRAPPC3 trafficking protein particle complex 3