BRD-K40373196_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K40373196_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
C6ORF62 chromosome 6 open reading frame 62
CANX calnexin
CD163 CD163 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLC Charcot-Leyden crystal galectin
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GLIPR1 GLI pathogenesis-related 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HYOU1 hypoxia up-regulated 1
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
MAGED1 melanoma antigen family D1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MDK midkine (neurite growth-promoting factor 2)
MMP7 matrix metallopeptidase 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPTX2 neuronal pentraxin II
NT5E 5'-nucleotidase, ecto (CD73)
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDLIM4 PDZ and LIM domain 4
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAP prosaposin
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SDF2L1 stromal cell-derived factor 2-like 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ARID1A AT rich interactive domain 1A (SWI-like)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
CCL19 chemokine (C-C motif) ligand 19
CES1 carboxylesterase 1
CLTC clathrin, heavy chain (Hc)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FASN fatty acid synthase
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HN1 hematological and neurological expressed 1
HOXC6 homeobox C6
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MKL2 MKL/myocardin-like 2
MRPS7 mitochondrial ribosomal protein S7
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP85 nucleoporin 85kDa
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCD protein kinase C, delta
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TGM2 transglutaminase 2
TNS3 tensin 3
TUBB2A tubulin, beta 2A class IIa
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
Funding