BRD-K41557448_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

74 genes differentially expressed following the BRD-K41557448_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM2 absent in melanoma 2
ANKRD10 ankyrin repeat domain 10
BASP1 brain abundant, membrane attached signal protein 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DKK1 dickkopf WNT signaling pathway inhibitor 1
FAM46A family with sequence similarity 46, member A
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GSTA4 glutathione S-transferase alpha 4
HACD1 3-hydroxyacyl-CoA dehydratase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOOK2 hook microtubule-tethering protein 2
IDO1 indoleamine 2,3-dioxygenase 1
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL2RB interleukin 2 receptor, beta
ITM2A integral membrane protein 2A
KIAA0125 KIAA0125
MAP7 microtubule-associated protein 7
MBOAT7 membrane bound O-acyltransferase domain containing 7
MRPS30 mitochondrial ribosomal protein S30
NUP210 nucleoporin 210kDa
PLAC8 placenta-specific 8
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB4A RAB4A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
S100A7 S100 calcium binding protein A7
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPA2 surfactant protein A2
SIAH2 siah E3 ubiquitin protein ligase 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SORD sorbitol dehydrogenase
SUB1 SUB1 homolog (S. cerevisiae)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10

decreased expression

Symbol Name
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ARHGAP29 Rho GTPase activating protein 29
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD9 CD9 molecule
CXCL14 chemokine (C-X-C motif) ligand 14
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
FGFR2 fibroblast growth factor receptor 2
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IPO13 importin 13
KCTD12 potassium channel tetramerization domain containing 12
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MT1X metallothionein 1X
RGCC regulator of cell cycle
SDC4 syndecan 4
STC1 stanniocalcin 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
Funding