BRD-K41731458_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K41731458_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ACKR3 atypical chemokine receptor 3
ARF1 ADP-ribosylation factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
C10ORF10 chromosome 10 open reading frame 10
CA1 carbonic anhydrase I
CCDC86 coiled-coil domain containing 86
CD36 CD36 molecule (thrombospondin receptor)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CELF2 CUGBP, Elav-like family member 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CREB3L2 cAMP responsive element binding protein 3-like 2
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DSP desmoplakin
EGFR epidermal growth factor receptor
EMX2 empty spiracles homeobox 2
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM3C family with sequence similarity 3, member C
FAM69A family with sequence similarity 69, member A
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
GSE1 Gse1 coiled-coil protein
GSTT1 glutathione S-transferase theta 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JCHAIN joining chain of multimeric IgA and IgM
KDM5B lysine (K)-specific demethylase 5B
LTBP2 latent transforming growth factor beta binding protein 2
MAP7 microtubule-associated protein 7
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MTSS1 metastasis suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1D myosin ID
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFD platelet derived growth factor D
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLXND1 plexin D1
PNKP polynucleotide kinase 3'-phosphatase
PPAP2B phosphatidic acid phosphatase type 2B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
RNASE4 ribonuclease, RNase A family, 4
SEPP1 selenoprotein P, plasma, 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TRIB3 tribbles pseudokinase 3
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
WARS tryptophanyl-tRNA synthetase
ZNF83 zinc finger protein 83

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNF cyclin F
CD24 CD24 molecule
CHGB chromogranin B
COL5A1 collagen, type V, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLD dihydrolipoamide dehydrogenase
DNTT DNA nucleotidylexotransferase
EBP emopamil binding protein (sterol isomerase)
ECM1 extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8B golgin A8 family, member B
GRB14 growth factor receptor-bound protein 14
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
KIAA0485 uncharacterized LOC57235
KIAA1033 KIAA1033
KRT14 keratin 14, type I
LAMB1 laminin, beta 1
LDLR low density lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MOK MOK protein kinase
MRPS16 mitochondrial ribosomal protein S16
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEU1 sialidase 1 (lysosomal sialidase)
NPY neuropeptide Y
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCAND1 SCAN domain containing 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SRSF6 serine/arginine-rich splicing factor 6
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TKTL1 transketolase-like 1
TSPYL5 TSPY-like 5
ZNF423 zinc finger protein 423
Funding