BRD-K41859756_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K41859756_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ANK2 ankyrin 2, neuronal
ARL1 ADP-ribosylation factor-like 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BAG3 BCL2-associated athanogene 3
CACYBP calcyclin binding protein
CD14 CD14 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CREB3L2 cAMP responsive element binding protein 3-like 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FICD FIC domain containing
FKBP11 FK506 binding protein 11, 19 kDa
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPE1 heat shock 10kDa protein 1
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IL32 interleukin 32
ISG20 interferon stimulated exonuclease gene 20kDa
MANF mesencephalic astrocyte-derived neurotrophic factor
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NANS N-acetylneuraminic acid synthase
NUCB2 nucleobindin 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PPIB peptidylprolyl isomerase B (cyclophilin B)
RAD9A RAD9 homolog A (S. pombe)
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SDF2L1 stromal cell-derived factor 2-like 1
SEC61B Sec61 beta subunit
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC35B1 solute carrier family 35, member B1
SRGN serglycin
TMED2 transmembrane emp24 domain trafficking protein 2
TP53 tumor protein p53
UGDH UDP-glucose 6-dehydrogenase
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
CHRDL1 chordin-like 1
CTSW cathepsin W
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DUSP6 dual specificity phosphatase 6
ERBB3 erb-b2 receptor tyrosine kinase 3
FZD7 frizzled class receptor 7
GSTM3 glutathione S-transferase mu 3 (brain)
HES1 hes family bHLH transcription factor 1
IRS1 insulin receptor substrate 1
MET MET proto-oncogene, receptor tyrosine kinase
PRSS23 protease, serine, 23
PTPN12 protein tyrosine phosphatase, non-receptor type 12
SMAD3 SMAD family member 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
TMEM2 transmembrane protein 2
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
WEE1 WEE1 G2 checkpoint kinase