BRD-K41895714_AS-605240_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K41895714_AS-605240_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADARB1 adenosine deaminase, RNA-specific, B1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMACR alpha-methylacyl-CoA racemase
ASCL1 achaete-scute family bHLH transcription factor 1
CA12 carbonic anhydrase XII
CCP110 centriolar coiled coil protein 110kDa
CDC45 cell division cycle 45
CPA3 carboxypeptidase A3 (mast cell)
CRYAB crystallin, alpha B
CTSH cathepsin H
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBLN1 fibulin 1
FBN2 fibrillin 2
FGF9 fibroblast growth factor 9
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPER1 G protein-coupled estrogen receptor 1
GSTA4 glutathione S-transferase alpha 4
GSTT1 glutathione S-transferase theta 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPB8 heat shock 22kDa protein 8
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KIAA0355 KIAA0355
KRT6A keratin 6A, type II
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRN3 leucine rich repeat neuronal 3
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGED1 melanoma antigen family D1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYLK myosin light chain kinase
NAMPT nicotinamide phosphoribosyltransferase
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOTCH3 notch 3
NUPR1 nuclear protein, transcriptional regulator, 1
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PODXL podocalyxin-like
PPAP2A phosphatidic acid phosphatase type 2A
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAME preferentially expressed antigen in melanoma
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A14 S100 calcium binding protein A14
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
CBFB core-binding factor, beta subunit
CCND1 cyclin D1
CCNE2 cyclin E2
CHN1 chimerin 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKLF chemokine-like factor
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTBP2 C-terminal binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPYSL3 dihydropyrimidinase-like 3
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GLIPR1 GLI pathogenesis-related 1
HMGA1 high mobility group AT-hook 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
ITM2C integral membrane protein 2C
KCTD12 potassium channel tetramerization domain containing 12
KIAA1033 KIAA1033
KIF14 kinesin family member 14
LUM lumican
MARCKS myristoylated alanine-rich protein kinase C substrate
MTFR1 mitochondrial fission regulator 1
NBPF10 neuroblastoma breakpoint family, member 10
NET1 neuroepithelial cell transforming 1
NPAS2 neuronal PAS domain protein 2
NPTX2 neuronal pentraxin II
PDE4B phosphodiesterase 4B, cAMP-specific
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC43A3 solute carrier family 43, member 3
TESC tescalcin
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFDP1 transcription factor Dp-1
TGIF2 TGFB-induced factor homeobox 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TM4SF1 transmembrane 4 L six family member 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZNF423 zinc finger protein 423
Funding