BRD-K41895714_AS-605240_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K41895714_AS-605240_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACKR3 atypical chemokine receptor 3
AKR1C3 aldo-keto reductase family 1, member C3
ANXA4 annexin A4
ARID5B AT rich interactive domain 5B (MRF1-like)
BECN1 beclin 1, autophagy related
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C1RL complement component 1, r subcomponent-like
C21ORF33 chromosome 21 open reading frame 33
CCNG2 cyclin G2
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CELF2 CUGBP, Elav-like family member 2
CXADR coxsackie virus and adenovirus receptor
DAPK1 death-associated protein kinase 1
DUSP22 dual specificity phosphatase 22
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM13A family with sequence similarity 13, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GLS glutaminase
GRAMD3 GRAM domain containing 3
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HLA-E major histocompatibility complex, class I, E
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
INSIG2 insulin induced gene 2
IRF9 interferon regulatory factor 9
ISG15 ISG15 ubiquitin-like modifier
KLHL24 kelch-like family member 24
KLHL9 kelch-like family member 9
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MFAP5 microfibrillar associated protein 5
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NREP neuronal regeneration related protein
NUPR1 nuclear protein, transcriptional regulator, 1
PBLD phenazine biosynthesis-like protein domain containing
PFKL phosphofructokinase, liver
PLCB4 phospholipase C, beta 4
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAME preferentially expressed antigen in melanoma
QPRT quinolinate phosphoribosyltransferase
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSRP1 arginine/serine-rich protein 1
SCP2 sterol carrier protein 2
SEPW1 selenoprotein W, 1
SESN1 sestrin 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35E2B solute carrier family 35, member E2B
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYT17 synaptotagmin XVII
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOB1 transducer of ERBB2, 1
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN3 tetraspanin 3
TST thiosulfate sulfurtransferase (rhodanese)
TTC3 tetratricopeptide repeat domain 3
TXNIP thioredoxin interacting protein
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
YPEL5 yippee-like 5 (Drosophila)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
AIM2 absent in melanoma 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA2 annexin A2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
BGN biglycan
BIRC5 baculoviral IAP repeat containing 5
C7 complement component 7
CAST calpastatin
CCDC109B coiled-coil domain containing 109B
CCNA2 cyclin A2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CDC25A cell division cycle 25A
CLIC1 chloride intracellular channel 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DCN decorin
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EGR2 early growth response 2
EIF5A eukaryotic translation initiation factor 5A
EPHA2 EPH receptor A2
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GAL galanin/GMAP prepropeptide
GINS2 GINS complex subunit 2 (Psf2 homolog)
GZMK granzyme K (granzyme 3; tryptase II)
HMGB2 high mobility group box 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA14 heat shock 70kDa protein 14
IER3 immediate early response 3
LBR lamin B receptor
LMNB2 lamin B2
MAP2K3 mitogen-activated protein kinase kinase 3
MCM10 minichromosome maintenance complex component 10
MMP9 matrix metallopeptidase 9
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYLK myosin light chain kinase
NES nestin
NOLC1 nucleolar and coiled-body phosphoprotein 1
NUP98 nucleoporin 98kDa
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRF1 perforin 1 (pore forming protein)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS5 regulator of G-protein signaling 5
RPP38 ribonuclease P/MRP 38kDa subunit
S100A10 S100 calcium binding protein A10
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SLIT2 slit homolog 2 (Drosophila)
SNAI2 snail family zinc finger 2
SPATS2L spermatogenesis associated, serine-rich 2-like
SRM spermidine synthase
STK17A serine/threonine kinase 17a
TAGLN transgelin
TM4SF1 transmembrane 4 L six family member 1
UBE2C ubiquitin-conjugating enzyme E2C
Funding