BRD-K41895714_AS-605240_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

265 genes differentially expressed following the BRD-K41895714_AS-605240_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHNAK2 AHNAK nucleoprotein 2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
APLP2 amyloid beta (A4) precursor-like protein 2
ASS1 argininosuccinate synthase 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C1ORF116 chromosome 1 open reading frame 116
C1R complement component 1, r subcomponent
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CALCOCO1 calcium binding and coiled-coil domain 1
CAPN1 calpain 1, (mu/I) large subunit
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CFB complement factor B
CFD complement factor D (adipsin)
CLDN7 claudin 7
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL4A5 collagen, type IV, alpha 5
CRABP2 cellular retinoic acid binding protein 2
CSTA cystatin A (stefin A)
CYB5A cytochrome b5 type A (microsomal)
DCAF6 DDB1 and CUL4 associated factor 6
DCN decorin
DDR1 discoidin domain receptor tyrosine kinase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
FAM117A family with sequence similarity 117, member A
FAM134B family with sequence similarity 134, member B
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSE1 Gse1 coiled-coil protein
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IL1B interleukin 1, beta
IL32 interleukin 32
KLHL24 kelch-like family member 24
KRT13 keratin 13, type I
KRT19 keratin 19, type I
KRT4 keratin 4, type II
LCN2 lipocalin 2
LTBP1 latent transforming growth factor beta binding protein 1
MEIS1 Meis homeobox 1
MME membrane metallo-endopeptidase
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MVP major vault protein
MXRA5 matrix-remodelling associated 5
MYL9 myosin, light chain 9, regulatory
NEBL nebulette
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
OPTN optineurin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDLIM1 PDZ and LIM domain 1
PDZD2 PDZ domain containing 2
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PSG5 pregnancy specific beta-1-glycoprotein 5
PTGES prostaglandin E synthase
R3HDM4 R3H domain containing 4
RAB25 RAB25, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
SCARB1 scavenger receptor class B, member 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SELENBP1 selenium binding protein 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIRT3 sirtuin 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPON2 spondin 2, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
ST14 suppression of tumorigenicity 14 (colon carcinoma)
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO synaptopodin
TAGLN2 transgelin 2
TCEAL1 transcription elongation factor A (SII)-like 1
TCEAL4 transcription elongation factor A (SII)-like 4
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM45A transmembrane protein 45A
TMOD1 tropomodulin 1
TNNC1 troponin C type 1 (slow)
TPM1 tropomyosin 1 (alpha)
TSC22D3 TSC22 domain family, member 3
TTC39A tetratricopeptide repeat domain 39A
UBE2H ubiquitin-conjugating enzyme E2H
VAV3 vav 3 guanine nucleotide exchange factor
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANPEP alanyl (membrane) aminopeptidase
AREG amphiregulin
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AXL AXL receptor tyrosine kinase
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CDCA8 cell division cycle associated 8
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS1B CDC28 protein kinase regulatory subunit 1B
COTL1 coactosin-like F-actin binding protein 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYR61 cysteine-rich, angiogenic inducer, 61
DBF4 DBF4 zinc finger
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DONSON downstream neighbor of SON
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EDNRB endothelin receptor type B
EGR1 early growth response 1
EGR3 early growth response 3
EXO1 exonuclease 1
FABP1 fatty acid binding protein 1, liver
FEN1 flap structure-specific endonuclease 1
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GTSE1 G-2 and S-phase expressed 1
HAT1 histone acetyltransferase 1
HBEGF heparin-binding EGF-like growth factor
HIST1H4C histone cluster 1, H4c
HJURP Holliday junction recognition protein
HMGA2 high mobility group AT-hook 2
HMGB2 high mobility group box 2
IER3 immediate early response 3
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LMNB1 lamin B1
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NAV3 neuron navigator 3
NCAPG non-SMC condensin I complex, subunit G
NCAPH non-SMC condensin I complex, subunit H
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NOP56 NOP56 ribonucleoprotein
NPY neuropeptide Y
NT5E 5'-nucleotidase, ecto (CD73)
PARP2 poly (ADP-ribose) polymerase 2
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRPF4 pre-mRNA processing factor 4
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RFC4 replication factor C (activator 1) 4, 37kDa
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
SNRPG small nuclear ribonucleoprotein polypeptide G
SPAG5 sperm associated antigen 5
SPATS2L spermatogenesis associated, serine-rich 2-like
SPC25 SPC25, NDC80 kinetochore complex component
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
STX1A syntaxin 1A (brain)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TACC3 transforming, acidic coiled-coil containing protein 3
TFAM transcription factor A, mitochondrial
TFF3 trefoil factor 3 (intestinal)
TIPIN TIMELESS interacting protein
TMEM97 transmembrane protein 97
TNC tenascin C
TPX2 TPX2, microtubule-associated
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZWINT ZW10 interacting kinetochore protein
Funding