BRD-K41918892_A 769662_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K41918892_A 769662_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
BASP1 brain abundant, membrane attached signal protein 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COBL cordon-bleu WH2 repeat protein
CXCL12 chemokine (C-X-C motif) ligand 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FAR2 fatty acyl CoA reductase 2
FHL1 four and a half LIM domains 1
FST follistatin
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS1 growth arrest-specific 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
INHBA inhibin, beta A
JUN jun proto-oncogene
LINC00341 long intergenic non-protein coding RNA 341
LPAR1 lysophosphatidic acid receptor 1
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MPO myeloperoxidase
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PIEZO1 piezo-type mechanosensitive ion channel component 1
PIP prolactin-induced protein
PSD3 pleckstrin and Sec7 domain containing 3
PXDN peroxidasin
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TFF1 trefoil factor 1
TPD52L1 tumor protein D52-like 1
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CA2 carbonic anhydrase II
CBR1 carbonyl reductase 1
CD163 CD163 molecule
CLEC2B C-type lectin domain family 2, member B
CTSH cathepsin H
CXCL10 chemokine (C-X-C motif) ligand 10
DICER1 dicer 1, ribonuclease type III
FGG fibrinogen gamma chain
GPATCH8 G patch domain containing 8
IGFBP1 insulin-like growth factor binding protein 1
ITGA6 integrin, alpha 6
KRT1 keratin 1, type II
KRT5 keratin 5, type II
LCN2 lipocalin 2
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
NFE2L2 nuclear factor, erythroid 2-like 2
NSG1 neuron specific gene family member 1
PDZK1IP1 PDZK1 interacting protein 1
PFN2 profilin 2
PNMAL1 paraneoplastic Ma antigen family-like 1
PODXL podocalyxin-like
S100A2 S100 calcium binding protein A2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SST somatostatin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VSIG4 V-set and immunoglobulin domain containing 4
Funding