BRD-K41925105_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K41925105_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIXDC1 DIX domain containing 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
GADD45B growth arrest and DNA-damage-inducible, beta
GPC3 glypican 3
HIST1H2BK histone cluster 1, H2bk
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
LDLR low density lipoprotein receptor
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXDN peroxidasin
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SFRP1 secreted frizzled-related protein 1
SH3YL1 SH3 and SYLF domain containing 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSPAN8 tetraspanin 8
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AHCY adenosylhomocysteinase
ANPEP alanyl (membrane) aminopeptidase
ANXA6 annexin A6
ASPN asporin
B3GNT1
BCHE butyrylcholinesterase
CD52 CD52 molecule
CDK1 cyclin-dependent kinase 1
CTSB cathepsin B
CXCL14 chemokine (C-X-C motif) ligand 14
DPYD dihydropyrimidine dehydrogenase
ECM1 extracellular matrix protein 1
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GOLGA8B golgin A8 family, member B
GREM1 gremlin 1, DAN family BMP antagonist
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI6 interferon, alpha-inducible protein 6
LPAR6 lysophosphatidic acid receptor 6
LYPLA1 lysophospholipase I
MRPL15 mitochondrial ribosomal protein L15
NMU neuromedin U
NUSAP1 nucleolar and spindle associated protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PFDN5 prefoldin subunit 5
PI3 peptidase inhibitor 3, skin-derived
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRDX3 peroxiredoxin 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC2 syndecan 2
SPRR1A small proline-rich protein 1A
STAB1 stabilin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
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