BRD-K42021584_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K42021584_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
C3AR1 complement component 3a receptor 1
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CLDN3 claudin 3
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
CYR61 cysteine-rich, angiogenic inducer, 61
DEFA5 defensin, alpha 5, Paneth cell-specific
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EPHA2 EPH receptor A2
ESM1 endothelial cell-specific molecule 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGL2 fibrinogen-like 2
FLNA filamin A, alpha
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GSE1 Gse1 coiled-coil protein
H1F0 H1 histone family, member 0
HBEGF heparin-binding EGF-like growth factor
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
INHBB inhibin, beta B
IRF6 interferon regulatory factor 6
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LDOC1 leucine zipper, down-regulated in cancer 1
LPP LIM domain containing preferred translocation partner in lipoma
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MGAM maltase-glucoamylase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEBL nebulette
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUAK1 NUAK family, SNF1-like kinase, 1
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PON3 paraoxonase 3
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SULF1 sulfatase 1
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
THBD thrombomodulin
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB1 tribbles pseudokinase 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
AKAP7 A kinase (PRKA) anchor protein 7
ANKRD10 ankyrin repeat domain 10
BST2 bone marrow stromal cell antigen 2
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
C5ORF30 chromosome 5 open reading frame 30
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDKN2A cyclin-dependent kinase inhibitor 2A
CLINT1 clathrin interactor 1
DCN decorin
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP22 dual specificity phosphatase 22
EED embryonic ectoderm development
EIF5 eukaryotic translation initiation factor 5
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM208A family with sequence similarity 208, member A
FASTKD5 FAST kinase domains 5
FBXO9 F-box protein 9
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GAS1 growth arrest-specific 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLPH3L golgi phosphoprotein 3-like
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IL6ST interleukin 6 signal transducer
IQGAP2 IQ motif containing GTPase activating protein 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0907 KIAA0907
LDHB lactate dehydrogenase B
LINC00341 long intergenic non-protein coding RNA 341
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGED1 melanoma antigen family D1
METTL3 methyltransferase like 3
NRIP3 nuclear receptor interacting protein 3
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PARP2 poly (ADP-ribose) polymerase 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLAC8 placenta-specific 8
PNISR PNN-interacting serine/arginine-rich protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
PRPF4B pre-mRNA processing factor 4B
RPL27A ribosomal protein L27a
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARDBP TAR DNA binding protein
TRAK2 trafficking protein, kinesin binding 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC119B unc-119 homolog B (C. elegans)
USP34 ubiquitin specific peptidase 34
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VLDLR very low density lipoprotein receptor
Funding