BRD-K42191735_buparlisib_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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63 genes differentially expressed following the BRD-K42191735_buparlisib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN6 calpain 6
CCL2 chemokine (C-C motif) ligand 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
COL9A3 collagen, type IX, alpha 3
COLEC12 collectin sub-family member 12
ELMO1 engulfment and cell motility 1
FBN2 fibrillin 2
FMOD fibromodulin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO4 forkhead box O4
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA4 golgin A4
GSN gelsolin
H2AFY H2A histone family, member Y
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL17RB interleukin 17 receptor B
MED1 mediator complex subunit 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
NDRG1 N-myc downstream regulated 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NPIPB3 nuclear pore complex interacting protein family, member B3
PCGF2 polycomb group ring finger 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP1 secreted frizzled-related protein 1
SIDT2 SID1 transmembrane family, member 2
TFF3 trefoil factor 3 (intestinal)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD47 CD47 molecule
CD52 CD52 molecule
CDC42 cell division cycle 42
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYCS cytochrome c, somatic
DHCR7 7-dehydrocholesterol reductase
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
F13A1 coagulation factor XIII, A1 polypeptide
GLIPR1 GLI pathogenesis-related 1
HAT1 histone acetyltransferase 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
JAG1 jagged 1
LAPTM4B lysosomal protein transmembrane 4 beta
LUM lumican
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PPAT phosphoribosyl pyrophosphate amidotransferase
RBM3 RNA binding motif (RNP1, RRM) protein 3
SFN stratifin
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
TFRC transferrin receptor
TLR4 toll-like receptor 4
TMEM126B transmembrane protein 126B
TSPAN8 tetraspanin 8
TXNDC9 thioredoxin domain containing 9