BRD-K42191735_buparlisib_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

122 genes differentially expressed following the BRD-K42191735_buparlisib_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACKR3 atypical chemokine receptor 3
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AMIGO2 adhesion molecule with Ig-like domain 2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
C1S complement component 1, s subcomponent
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHEK2 checkpoint kinase 2
CHI3L2 chitinase 3-like 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DLK1 delta-like 1 homolog (Drosophila)
DST dystonin
FAXDC2 fatty acid hydroxylase domain containing 2
FBN2 fibrillin 2
FOLR1 folate receptor 1 (adult)
GPM6B glycoprotein M6B
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
IFI27 interferon, alpha-inducible protein 27
KAT6B K(lysine) acetyltransferase 6B
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LRRC16A leucine rich repeat containing 16A
MAP2K5 mitogen-activated protein kinase kinase 5
METTL7A methyltransferase like 7A
MGP matrix Gla protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NOV nephroblastoma overexpressed
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRAME preferentially expressed antigen in melanoma
PRKCA protein kinase C, alpha
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TARBP1 TAR (HIV-1) RNA binding protein 1
THBS1 thrombospondin 1
TMEM100 transmembrane protein 100
TRAK2 trafficking protein, kinesin binding 2
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAM1 vascular cell adhesion molecule 1
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ADM adrenomedullin
AMD1 adenosylmethionine decarboxylase 1
AQP3 aquaporin 3 (Gill blood group)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CYB561 cytochrome b561
DEGS1 delta(4)-desaturase, sphingolipid 1
EGR1 early growth response 1
EGR2 early growth response 2
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JMJD6 jumonji domain containing 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
MICALL1 MICAL-like 1
NPR3 natriuretic peptide receptor 3
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM2 PDZ and LIM domain 2 (mystique)
PEA15 phosphoprotein enriched in astrocytes 15
PIP prolactin-induced protein
PSPH phosphoserine phosphatase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PXDC1 PX domain containing 1
RGS2 regulator of G-protein signaling 2
RNF219 ring finger protein 219
RPIA ribose 5-phosphate isomerase A
S100A7 S100 calcium binding protein A7
SATB1 SATB homeobox 1
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPP1 secreted phosphoprotein 1
SPRR1A small proline-rich protein 1A
SPRR2B small proline-rich protein 2B
TES testin LIM domain protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM204 transmembrane protein 204
UFM1 ubiquitin-fold modifier 1
UPK1B uroplakin 1B
Funding