BRD-K42191735_buparlisib_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K42191735_buparlisib_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSM3 acyl-CoA synthetase medium-chain family member 3
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
BTG2 BTG family, member 2
C14ORF132 chromosome 14 open reading frame 132
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CST1 cystatin SN
CST3 cystatin C
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DST dystonin
DUSP4 dual specificity phosphatase 4
EFHC1 EF-hand domain (C-terminal) containing 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
FOXD1 forkhead box D1
GCC2 GRIP and coiled-coil domain containing 2
GDF15 growth differentiation factor 15
GOLGA8A golgin A8 family, member A
GOLGA8H golgin A8 family, member H
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GRN granulin
GSTZ1 glutathione S-transferase zeta 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
KDM3A lysine (K)-specific demethylase 3A
KIF20A kinesin family member 20A
KLHDC2 kelch domain containing 2
LAMP2 lysosomal-associated membrane protein 2
LEPROT leptin receptor overlapping transcript
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LITAF lipopolysaccharide-induced TNF factor
LRP10 low density lipoprotein receptor-related protein 10
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MOAP1 modulator of apoptosis 1
MOK MOK protein kinase
MTSS1 metastasis suppressor 1
MVP major vault protein
MYO6 myosin VI
NDRG1 N-myc downstream regulated 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHF20 PHD finger protein 20
PLCB4 phospholipase C, beta 4
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRAME preferentially expressed antigen in melanoma
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RGS2 regulator of G-protein signaling 2
RSRP1 arginine/serine-rich protein 1
RTN2 reticulon 2
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SECISBP2L SECIS binding protein 2-like
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEPT10 septin 10
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC38A2 solute carrier family 38, member 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPAG4 sperm associated antigen 4
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TRIM22 tripartite motif containing 22
TRIP6 thyroid hormone receptor interactor 6
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACOT7 acyl-CoA thioesterase 7
ADGRG2 adhesion G protein-coupled receptor G2
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK2 adenylate kinase 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C1ORF116 chromosome 1 open reading frame 116
CCL5 chemokine (C-C motif) ligand 5
CCND3 cyclin D3
CCNF cyclin F
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHPT1 choline phosphotransferase 1
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A1 collagen, type V, alpha 1
CORO1A coronin, actin binding protein, 1A
CYB561 cytochrome b561
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS11 dehydrogenase/reductase (SDR family) member 11
EBP emopamil binding protein (sterol isomerase)
EPHA3 EPH receptor A3
FADS1 fatty acid desaturase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
GJA1 gap junction protein, alpha 1, 43kDa
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGF1 insulin-like growth factor 1 (somatomedin C)
IGL immunoglobulin lambda locus
ITM2A integral membrane protein 2A
KRT6A keratin 6A, type II
KYNU kynureninase
LAPTM5 lysosomal protein transmembrane 5
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LUM lumican
MALL mal, T-cell differentiation protein-like
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
PI3 peptidase inhibitor 3, skin-derived
PNP purine nucleoside phosphorylase
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRMT1 protein arginine methyltransferase 1
QDPR quinoid dihydropteridine reductase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A7 S100 calcium binding protein A7
SFTPB surfactant protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
TMEM45A transmembrane protein 45A
TUBB6 tubulin, beta 6 class V
UBE2N ubiquitin-conjugating enzyme E2N
UPP1 uridine phosphorylase 1
Funding