BRD-K42191735_buparlisib_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K42191735_buparlisib_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
ACTG2 actin, gamma 2, smooth muscle, enteric
ARID5B AT rich interactive domain 5B (MRF1-like)
ASRGL1 asparaginase like 1
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
C5AR1 complement component 5a receptor 1
CD36 CD36 molecule (thrombospondin receptor)
CRABP2 cellular retinoic acid binding protein 2
CXCL14 chemokine (C-X-C motif) ligand 14
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
FAM13A family with sequence similarity 13, member A
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FOS FBJ murine osteosarcoma viral oncogene homolog
GPNMB glycoprotein (transmembrane) nmb
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDE insulin-degrading enzyme
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KIAA0355 KIAA0355
KLK11 kallikrein-related peptidase 11
MCOLN1 mucolipin 1
OXTR oxytocin receptor
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDZK1IP1 PDZK1 interacting protein 1
PLIN2 perilipin 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A2 secretoglobin, family 2A, member 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator
WT1 Wilms tumor 1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
CD34 CD34 molecule
CHGB chromogranin B
HDGFRP3 hepatoma-derived growth factor, related protein 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KRT17 keratin 17, type I
KRT19 keratin 19, type I
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
SATB1 SATB homeobox 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAP25 synaptosomal-associated protein, 25kDa
SQLE squalene epoxidase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
XYLT1 xylosyltransferase I
Funding