BRD-K42436189_AZ20_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

187 genes differentially expressed following the BRD-K42436189_AZ20_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CD151 CD151 molecule (Raph blood group)
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHRDL1 chordin-like 1
CLCA4 chloride channel accessory 4
CLEC2B C-type lectin domain family 2, member B
CLTB clathrin, light chain B
COL1A1 collagen, type I, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CTTN cortactin
CYR61 cysteine-rich, angiogenic inducer, 61
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DFNA5 deafness, autosomal dominant 5
DUOX2 dual oxidase 2
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELL2 elongation factor, RNA polymerase II, 2
FDXR ferredoxin reductase
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
ISG20 interferon stimulated exonuclease gene 20kDa
ISOC1 isochorismatase domain containing 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGB5 integrin, beta 5
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KRT18 keratin 18, type I
LAMC2 laminin, gamma 2
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MET MET proto-oncogene, receptor tyrosine kinase
MICALL1 MICAL-like 1
MSN moesin
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT2A metallothionein 2A
MVP major vault protein
MXRA5 matrix-remodelling associated 5
NCOR2 nuclear receptor corepressor 2
NNMT nicotinamide N-methyltransferase
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
POSTN periostin, osteoblast specific factor
RB1CC1 RB1-inducible coiled-coil 1
RBKS ribokinase
RIOK3 RIO kinase 3
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A18 solute carrier family 22, member 18
SMAD3 SMAD family member 3
SQRDL sulfide quinone reductase-like (yeast)
SQSTM1 sequestosome 1
STOM stomatin
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPP1 tripeptidyl peptidase I
TUBB6 tubulin, beta 6 class V
TWF2 twinfilin actin binding protein 2
UPK1B uroplakin 1B
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
AUTS2 autism susceptibility candidate 2
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CENPU centromere protein U
CPVL carboxypeptidase, vitellogenic-like
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
EPHA4 EPH receptor A4
FANCG Fanconi anemia, complementation group G
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFR2 fibroblast growth factor receptor 2
FXYD6 FXYD domain containing ion transport regulator 6
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP8 GTP-binding protein 8 (putative)
H2AFX H2A histone family, member X
HDGFRP3 hepatoma-derived growth factor, related protein 3
HELLS helicase, lymphoid-specific
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
KIAA0101 KIAA0101
KIF11 kinesin family member 11
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MB myoglobin
MBOAT7 membrane bound O-acyltransferase domain containing 7
MCAM melanoma cell adhesion molecule
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MSH2 mutS homolog 2
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PRKCH protein kinase C, eta
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PXMP2 peroxisomal membrane protein 2, 22kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPA1 replication protein A1, 70kDa
RRM2 ribonucleotide reductase M2
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SHB Src homology 2 domain containing adaptor protein B
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD1 SMAD family member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TCTN1 tectonic family member 1
TFRC transferrin receptor
TK1 thymidine kinase 1, soluble
TOP2A topoisomerase (DNA) II alpha 170kDa
TRD T cell receptor delta locus
TTN titin
UBE2C ubiquitin-conjugating enzyme E2C
XIST X inactive specific transcript (non-protein coding)
ZWINT ZW10 interacting kinetochore protein
Funding