BRD-K42489623_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K42489623_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
CA9 carbonic anhydrase IX
CD163 CD163 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
FAIM Fas apoptotic inhibitory molecule
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHD immunoglobulin heavy constant delta
KRT6A keratin 6A, type II
LPAR1 lysophosphatidic acid receptor 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR0B1 nuclear receptor subfamily 0, group B, member 1
NSG1 neuron specific gene family member 1
PFN2 profilin 2
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A8 S100 calcium binding protein A8
SFN stratifin
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
TMEM176B transmembrane protein 176B
TRDV3 T cell receptor delta variable 3
TSKU tsukushi, small leucine rich proteoglycan
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ANXA3 annexin A3
AREG amphiregulin
CXCL12 chemokine (C-X-C motif) ligand 12
DLD dihydrolipoamide dehydrogenase
DLG5 discs, large homolog 5 (Drosophila)
DMD dystrophin
EMP1 epithelial membrane protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
HOXC6 homeobox C6
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
ISG15 ISG15 ubiquitin-like modifier
LGALS1 lectin, galactoside-binding, soluble, 1
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MX1 MX dynamin-like GTPase 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
QPRT quinolinate phosphoribosyltransferase
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM22 tripartite motif containing 22
TSPYL5 TSPY-like 5
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF217 zinc finger protein 217
Funding