BRD-K42500029_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K42500029_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CD69 CD69 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRABP2 cellular retinoic acid binding protein 2
CTH cystathionine gamma-lyase
CYB561 cytochrome b561
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FAM69A family with sequence similarity 69, member A
FGG fibrinogen gamma chain
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IFRD1 interferon-related developmental regulator 1
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT23 keratin 23, type I
MARS methionyl-tRNA synthetase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PYCR1 pyrroline-5-carboxylate reductase 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SARS seryl-tRNA synthetase
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIX2 SIX homeobox 2
SLC38A1 solute carrier family 38, member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS2 sorbin and SH3 domain containing 2
STC2 stanniocalcin 2
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AZU1 azurocidin 1
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
CBR3 carbonyl reductase 3
CD99 CD99 molecule
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSG cathepsin G
DEFB1 defensin, beta 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
ELANE elastase, neutrophil expressed
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FAM46A family with sequence similarity 46, member A
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPX3 glutathione peroxidase 3
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
OLFM4 olfactomedin 4
PI3 peptidase inhibitor 3, skin-derived
PRTN3 proteinase 3
S100A10 S100 calcium binding protein A10
S100A7 S100 calcium binding protein A7
STC1 stanniocalcin 1
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
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