BRD-K42679050_Y-27152_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

144 genes differentially expressed following the BRD-K42679050_Y-27152_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ANPEP alanyl (membrane) aminopeptidase
ARG2 arginase 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD40 CD40 molecule, TNF receptor superfamily member 5
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLCA4 chloride channel accessory 4
CLDN7 claudin 7
CLDN8 claudin 8
COG7 component of oligomeric golgi complex 7
CSTA cystatin A (stefin A)
CTNND1 catenin (cadherin-associated protein), delta 1
CTSH cathepsin H
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
EHF ets homologous factor
EPCAM epithelial cell adhesion molecule
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FRZB frizzled-related protein
FTH1 ferritin, heavy polypeptide 1
FZD1 frizzled class receptor 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
H2AFV H2A histone family, member V
HIST1H1C histone cluster 1, H1c
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HK2 hexokinase 2
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA9 heat shock 70kDa protein 9 (mortalin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
JOSD1 Josephin domain containing 1
KIF1BP KIF1 binding protein
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBOAT7 membrane bound O-acyltransferase domain containing 7
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MUC4 mucin 4, cell surface associated
NVL nuclear VCP-like
OLFM4 olfactomedin 4
ORC1 origin recognition complex, subunit 1
OSBPL10 oxysterol binding protein-like 10
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
PRR15L proline rich 15-like
PRSS8 protease, serine, 8
PRUNE2 prune homolog 2 (Drosophila)
PTPRK protein tyrosine phosphatase, receptor type, K
RAB21 RAB21, member RAS oncogene family
RAB25 RAB25, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RTN1 reticulon 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNN stannin
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBXA2R thromboxane A2 receptor
TCTA T-cell leukemia translocation altered
TESK1 testis-specific kinase 1
TMC5 transmembrane channel-like 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
TRAP1 TNF receptor-associated protein 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA5 annexin A5
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
C1S complement component 1, s subcomponent
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD59 CD59 molecule, complement regulatory protein
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLEC2B C-type lectin domain family 2, member B
CPVL carboxypeptidase, vitellogenic-like
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
EMP3 epithelial membrane protein 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLT1B golgi transport 1B
GSTA4 glutathione S-transferase alpha 4
HOXC6 homeobox C6
JADE1 jade family PHD finger 1
KIAA0125 KIAA0125
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
MAGED1 melanoma antigen family D1
MYO6 myosin VI
PCDH9 protocadherin 9
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCZ protein kinase C, zeta
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RGS2 regulator of G-protein signaling 2
RPS11 ribosomal protein S11
SELPLG selectin P ligand
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPRR2B small proline-rich protein 2B
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TESC tescalcin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TM4SF1 transmembrane 4 L six family member 1
TUBB2B tubulin, beta 2B class IIb
TXNDC9 thioredoxin domain containing 9
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican