| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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321 genes differentially expressed following the BRD-K42918627_GSK-2126458_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| AHNAK2 | AHNAK nucleoprotein 2 |
| ANKRD10 | ankyrin repeat domain 10 |
| ANKRD36B | ankyrin repeat domain 36B |
| APOD | apolipoprotein D |
| ARMCX1 | armadillo repeat containing, X-linked 1 |
| ATF4 | activating transcription factor 4 |
| ATHL1 | ATH1, acid trehalase-like 1 (yeast) |
| ATP9A | ATPase, class II, type 9A |
| BCL2L2 | BCL2-like 2 |
| BHLHE41 | basic helix-loop-helix family, member e41 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CADM1 | cell adhesion molecule 1 |
| CANX | calnexin |
| CAPN3 | calpain 3, (p94) |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
| CCPG1 | cell cycle progression 1 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDIPT | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| CDK12 | cyclin-dependent kinase 12 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) |
| COL11A1 | collagen, type XI, alpha 1 |
| COL8A2 | collagen, type VIII, alpha 2 |
| COL9A2 | collagen, type IX, alpha 2 |
| COMP | cartilage oligomeric matrix protein |
| COX7A1 | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
| CPQ | carboxypeptidase Q |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide |
| CTSK | cathepsin K |
| DDIT3 | DNA-damage-inducible transcript 3 |
| DIAPH2 | diaphanous-related formin 2 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 |
| DPP4 | dipeptidyl-peptidase 4 |
| DUSP4 | dual specificity phosphatase 4 |
| DYNLT3 | dynein, light chain, Tctex-type 3 |
| EFNA1 | ephrin-A1 |
| EPN2 | epsin 2 |
| ETV1 | ets variant 1 |
| FAM129A | family with sequence similarity 129, member A |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B |
| GAB2 | GRB2-associated binding protein 2 |
| GATAD1 | GATA zinc finger domain containing 1 |
| GLS | glutaminase |
| GPNMB | glycoprotein (transmembrane) nmb |
| GREM1 | gremlin 1, DAN family BMP antagonist |
| GSN | gelsolin |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 |
| HBP1 | HMG-box transcription factor 1 |
| HDAC9 | histone deacetylase 9 |
| HIST1H2AC | histone cluster 1, H2ac |
| HLA-E | major histocompatibility complex, class I, E |
| HMOX1 | heme oxygenase 1 |
| ICAM1 | intercellular adhesion molecule 1 |
| IFRD1 | interferon-related developmental regulator 1 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IGF2R | insulin-like growth factor 2 receptor |
| IL1B | interleukin 1, beta |
| IPO13 | importin 13 |
| IRS1 | insulin receptor substrate 1 |
| IRS2 | insulin receptor substrate 2 |
| ISG20 | interferon stimulated exonuclease gene 20kDa |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KIAA1033 | KIAA1033 |
| KLF5 | Kruppel-like factor 5 (intestinal) |
| KLHL21 | kelch-like family member 21 |
| KYNU | kynureninase |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LETMD1 | LETM1 domain containing 1 |
| LOC100272216 | uncharacterized LOC100272216 |
| LOC399491 | |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAGEA3 | melanoma antigen family A3 |
| MARCH6 | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase |
| MET | MET proto-oncogene, receptor tyrosine kinase |
| MFAP5 | microfibrillar associated protein 5 |
| MME | membrane metallo-endopeptidase |
| MT1X | metallothionein 1X |
| MTMR11 | myotubularin related protein 11 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| N4BP2L2 | NEDD4 binding protein 2-like 2 |
| NDRG1 | N-myc downstream regulated 1 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) |
| NEB | nebulin |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| NIT1 | nitrilase 1 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) |
| NOV | nephroblastoma overexpressed |
| NPC1 | Niemann-Pick disease, type C1 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 |
| NRN1 | neuritin 1 |
| NT5E | 5'-nucleotidase, ecto (CD73) |
| NUPR1 | nuclear protein, transcriptional regulator, 1 |
| OFD1 | oral-facial-digital syndrome 1 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase |
| OPTN | optineurin |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 |
| PARP6 | poly (ADP-ribose) polymerase family, member 6 |
| PARVA | parvin, alpha |
| PDE4DIP | phosphodiesterase 4D interacting protein |
| PDZRN3 | PDZ domain containing ring finger 3 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 |
| PLXNA1 | plexin A1 |
| PMP22 | peripheral myelin protein 22 |
| POPDC3 | popeye domain containing 3 |
| PRKD1 | protein kinase D1 |
| PRUNE2 | prune homolog 2 (Drosophila) |
| QPCT | glutaminyl-peptide cyclotransferase |
| RAB29 | RAB29, member RAS oncogene family |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit |
| RALGDS | ral guanine nucleotide dissociation stimulator |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B |
| RGS10 | regulator of G-protein signaling 10 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
| RRAGC | Ras-related GTP binding C |
| RSL1D1 | ribosomal L1 domain containing 1 |
| RSRP1 | arginine/serine-rich protein 1 |
| RUNX1T1 | runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
| SAMD4A | sterile alpha motif domain containing 4A |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SATB2 | SATB homeobox 2 |
| SDCBP | syndecan binding protein (syntenin) |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 |
| SLC22A18 | solute carrier family 22, member 18 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 |
| SLC35E2B | solute carrier family 35, member E2B |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 |
| SMAP1 | small ArfGAP 1 |
| SOD2 | superoxide dismutase 2, mitochondrial |
| SPATA20 | spermatogenesis associated 20 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 |
| SQSTM1 | sequestosome 1 |
| STX1A | syntaxin 1A (brain) |
| SULF1 | sulfatase 1 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa |
| TPP1 | tripeptidyl peptidase I |
| TRIM2 | tripartite motif containing 2 |
| TRPS1 | trichorhinophalangeal syndrome I |
| TRPV2 | transient receptor potential cation channel, subfamily V, member 2 |
| TSC22D1 | TSC22 domain family, member 1 |
| TSC22D3 | TSC22 domain family, member 3 |
| VAT1 | vesicle amine transport 1 |
| VAV3 | vav 3 guanine nucleotide exchange factor |
| VEGFA | vascular endothelial growth factor A |
| VEGFC | vascular endothelial growth factor C |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) |
| XYLT1 | xylosyltransferase I |
| YPEL5 | yippee-like 5 (Drosophila) |
| ZFP36 | ZFP36 ring finger protein |
| ZNF277 | zinc finger protein 277 |
| Symbol | Name |
|---|---|
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 |
| ALDOC | aldolase C, fructose-bisphosphate |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E |
| AQP3 | aquaporin 3 (Gill blood group) |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta |
| ASF1A | anti-silencing function 1A histone chaperone |
| ASF1B | anti-silencing function 1B histone chaperone |
| ATAD2 | ATPase family, AAA domain containing 2 |
| AURKA | aurora kinase A |
| AURKB | aurora kinase B |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BRCA1 | breast cancer 1, early onset |
| CCNA2 | cyclin A2 |
| CCND2 | cyclin D2 |
| CCNE2 | cyclin E2 |
| CCNF | cyclin F |
| CDC25A | cell division cycle 25A |
| CDC42 | cell division cycle 42 |
| CDC6 | cell division cycle 6 |
| CDK1 | cyclin-dependent kinase 1 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPF | centromere protein F, 350/400kDa |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CLU | clusterin |
| CNN3 | calponin 3, acidic |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 |
| CYB5A | cytochrome b5 type A (microsomal) |
| DBF4 | DBF4 zinc finger |
| DEFB1 | defensin, beta 1 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| E2F8 | E2F transcription factor 8 |
| EBP | emopamil binding protein (sterol isomerase) |
| ECI2 | enoyl-CoA delta isomerase 2 |
| EIF4E | eukaryotic translation initiation factor 4E |
| EXOSC9 | exosome component 9 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM162A | family with sequence similarity 162, member A |
| FEN1 | flap structure-specific endonuclease 1 |
| FGFR3 | fibroblast growth factor receptor 3 |
| FSTL1 | follistatin-like 1 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GLIPR1 | GLI pathogenesis-related 1 |
| GMNN | geminin, DNA replication inhibitor |
| HAT1 | histone acetyltransferase 1 |
| HDAC2 | histone deacetylase 2 |
| HILPDA | hypoxia inducible lipid droplet-associated |
| HIST1H4C | histone cluster 1, H4c |
| HLTF | helicase-like transcription factor |
| HMGB2 | high mobility group box 2 |
| HMGB3 | high mobility group box 3 |
| HN1 | hematological and neurological expressed 1 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 |
| HSPA14 | heat shock 70kDa protein 14 |
| HSPA1A | heat shock 70kDa protein 1A |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| KIF18B | kinesin family member 18B |
| KIF20A | kinesin family member 20A |
| KRT5 | keratin 5, type II |
| LBR | lamin B receptor |
| LIG1 | ligase I, DNA, ATP-dependent |
| LMNB1 | lamin B1 |
| LMNB2 | lamin B2 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) |
| LPL | lipoprotein lipase |
| LRRC17 | leucine rich repeat containing 17 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LSM4 | LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LSM6 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LTF | lactotransferrin |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MCAM | melanoma cell adhesion molecule |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM2 | minichromosome maintenance complex component 2 |
| MCM3 | minichromosome maintenance complex component 3 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM5 | minichromosome maintenance complex component 5 |
| MCM6 | minichromosome maintenance complex component 6 |
| MELK | maternal embryonic leucine zipper kinase |
| MKI67 | marker of proliferation Ki-67 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYCBP | MYC binding protein |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) |
| NEK2 | NIMA-related kinase 2 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| NXT1 | nuclear transport factor 2-like export factor 1 |
| OIP5 | Opa interacting protein 5 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase |
| PBK | PDZ binding kinase |
| PBX2 | pre-B-cell leukemia homeobox 2 |
| PCNA | proliferating cell nuclear antigen |
| PGAM1 | phosphoglycerate mutase 1 (brain) |
| PLAC8 | placenta-specific 8 |
| PLK4 | polo-like kinase 4 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| POLR3K | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa |
| PPARG | peroxisome proliferator-activated receptor gamma |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) |
| PRKCB | protein kinase C, beta |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| PSPH | phosphoserine phosphatase |
| PSRC1 | proline/serine-rich coiled-coil 1 |
| RAD51 | RAD51 recombinase |
| RAD51C | RAD51 paralog C |
| RBBP8 | retinoblastoma binding protein 8 |
| RBP1 | retinol binding protein 1, cellular |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RGS2 | regulator of G-protein signaling 2 |
| RNASEH2A | ribonuclease H2, subunit A |
| RPA3 | replication protein A3, 14kDa |
| RRM2 | ribonucleotide reductase M2 |
| S100A8 | S100 calcium binding protein A8 |
| SELT | selenoprotein T |
| SEPP1 | selenoprotein P, plasma, 1 |
| SFN | stratifin |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SIVA1 | SIVA1, apoptosis-inducing factor |
| SKP1 | S-phase kinase-associated protein 1 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SNRNP25 | small nuclear ribonucleoprotein 25kDa (U11/U12) |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G |
| SPARCL1 | SPARC-like 1 (hevin) |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| SRSF7 | serine/arginine-rich splicing factor 7 |
| STMN1 | stathmin 1 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 |
| TK1 | thymidine kinase 1, soluble |
| TMEM14A | transmembrane protein 14A |
| TMPO | thymopoietin |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TSPAN13 | tetraspanin 13 |
| TUBG1 | tubulin, gamma 1 |
| TYMS | thymidylate synthetase |
| VRK1 | vaccinia related kinase 1 |
| WT1 | Wilms tumor 1 |
| YME1L1 | YME1-like 1 ATPase |
| ZFP36L1 | ZFP36 ring finger protein-like 1 |
| ZWINT | ZW10 interacting kinetochore protein |
