BRD-K42918627_GSK-2126458_HCC515_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K42918627_GSK-2126458_HCC515_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASCL1 achaete-scute family bHLH transcription factor 1
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C6ORF48 chromosome 6 open reading frame 48
CCP110 centriolar coiled coil protein 110kDa
CD163 CD163 molecule
CD93 CD93 molecule
COL11A1 collagen, type XI, alpha 1
CTGF connective tissue growth factor
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
EAPP E2F-associated phosphoprotein
EFNA1 ephrin-A1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4B eukaryotic translation initiation factor 4B
FABP4 fatty acid binding protein 4, adipocyte
FOXO4 forkhead box O4
GAA glucosidase, alpha; acid
GLTSCR2 glioma tumor suppressor candidate region gene 2
GPX3 glutathione peroxidase 3
HBP1 HMG-box transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
IGBP1 immunoglobulin (CD79A) binding protein 1
JUP junction plakoglobin
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LETMD1 LETM1 domain containing 1
LXN latexin
MAGED2 melanoma antigen family D2
MAP7 microtubule-associated protein 7
MED13L mediator complex subunit 13-like
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MXRA5 matrix-remodelling associated 5
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NNMT nicotinamide N-methyltransferase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDGFRL platelet-derived growth factor receptor-like
PGLS 6-phosphogluconolactonase
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKCH protein kinase C, eta
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RNF103 ring finger protein 103
RPL22 ribosomal protein L22
RPL31 ribosomal protein L31
RPS11 ribosomal protein S11
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SFRP4 secreted frizzled-related protein 4
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
STK10 serine/threonine kinase 10
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D3 TSC22 domain family, member 3
TSG101 tumor susceptibility 101
TSPAN4 tetraspanin 4
UGDH UDP-glucose 6-dehydrogenase
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZMYM2 zinc finger, MYM-type 2

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPU centromere protein U
CKB creatine kinase, brain
CTPS1 CTP synthase 1
CTSG cathepsin G
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ENO2 enolase 2 (gamma, neuronal)
FEN1 flap structure-specific endonuclease 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPER1 G protein-coupled estrogen receptor 1
H2AFX H2A histone family, member X
IGFBP3 insulin-like growth factor binding protein 3
JMJD6 jumonji domain containing 6
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MELK maternal embryonic leucine zipper kinase
MMP12 matrix metallopeptidase 12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NES nestin
NOP56 NOP56 ribonucleoprotein
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PKM pyruvate kinase, muscle
PPAP2B phosphatidic acid phosphatase type 2B
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RRM2 ribonucleotide reductase M2
SPAG5 sperm associated antigen 5
SSBP2 single-stranded DNA binding protein 2
TCL1A T-cell leukemia/lymphoma 1A
TK1 thymidine kinase 1, soluble
TMEM47 transmembrane protein 47
TNC tenascin C
TRIP13 thyroid hormone receptor interactor 13
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
VRK1 vaccinia related kinase 1
Funding