BRD-K42918627_GSK-2126458_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K42918627_GSK-2126458_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANXA4 annexin A4
ARG1 arginase 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C1RL complement component 1, r subcomponent-like
C5 complement component 5
C6ORF48 chromosome 6 open reading frame 48
CALML5 calmodulin-like 5
CAMLG calcium modulating ligand
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFB complement factor B
COBL cordon-bleu WH2 repeat protein
CP ceruloplasmin (ferroxidase)
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYTH1 cytohesin 1
DEFB1 defensin, beta 1
EIF4B eukaryotic translation initiation factor 4B
ERBB3 erb-b2 receptor tyrosine kinase 3
F5 coagulation factor V (proaccelerin, labile factor)
FAM46A family with sequence similarity 46, member A
FAM8A1 family with sequence similarity 8, member A1
FAXDC2 fatty acid hydroxylase domain containing 2
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FGL1 fibrinogen-like 1
FMO5 flavin containing monooxygenase 5
FOXN3 forkhead box N3
FOXO4 forkhead box O4
GABARAPL1 GABA(A) receptor-associated protein like 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLS glutaminase
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
GRN granulin
GSDMB gasdermin B
GSTA4 glutathione S-transferase alpha 4
HDAC6 histone deacetylase 6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3
KLHL24 kelch-like family member 24
LEPR leptin receptor
LETMD1 LETM1 domain containing 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LOX lysyl oxidase
MET MET proto-oncogene, receptor tyrosine kinase
MKRN1 makorin ring finger protein 1
MTSS1 metastasis suppressor 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
PCGF2 polycomb group ring finger 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPAP2B phosphatidic acid phosphatase type 2B
PRAF2 PRA1 domain family, member 2
PROM1 prominin 1
PYGL phosphorylase, glycogen, liver
RAB4A RAB4A, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RGN regucalcin
RNASE4 ribonuclease, RNase A family, 4
RPL39L ribosomal protein L39-like
RPS14P3 ribosomal protein S14 pseudogene 3
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT2 SID1 transmembrane family, member 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR3 transforming growth factor, beta receptor III
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK1 trafficking protein, kinesin binding 1
TSC2 tuberous sclerosis 2
TSPAN3 tetraspanin 3
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
WDR45 WD repeat domain 45
WFDC2 WAP four-disulfide core domain 2
ZNF277 zinc finger protein 277

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ANXA1 annexin A1
ANXA3 annexin A3
ATAD2 ATPase family, AAA domain containing 2
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
ENOPH1 enolase-phosphatase 1
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FEN1 flap structure-specific endonuclease 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HMGB2 high mobility group box 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
KIF20A kinesin family member 20A
KLK10 kallikrein-related peptidase 10
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MSMO1 methylsterol monooxygenase 1
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEK2 NIMA-related kinase 2
NES nestin
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PEA15 phosphoprotein enriched in astrocytes 15
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLN sarcolipin
SPC25 SPC25, NDC80 kinetochore complex component
SPRR3 small proline-rich protein 3
STMN1 stathmin 1
TAGLN transgelin
TFDP1 transcription factor Dp-1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIP13 thyroid hormone receptor interactor 13
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
VCAN versican
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZWINT ZW10 interacting kinetochore protein
Funding