| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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273 genes differentially expressed following the BRD-K42918627_GSK-2126458_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase |
| ACOX2 | acyl-CoA oxidase 2, branched chain |
| ADCK3 | aarF domain containing kinase 3 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide |
| AHSG | alpha-2-HS-glycoprotein |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| ALDH6A1 | aldehyde dehydrogenase 6 family, member A1 |
| AMACR | alpha-methylacyl-CoA racemase |
| ANG | angiogenin, ribonuclease, RNase A family, 5 |
| APOA2 | apolipoprotein A-II |
| APOC1 | apolipoprotein C-I |
| APOC2 | apolipoprotein C-II |
| APOE | apolipoprotein E |
| APOM | apolipoprotein M |
| ATP10A | ATPase, class V, type 10A |
| BAG6 | BCL2-associated athanogene 6 |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 |
| C10ORF10 | chromosome 10 open reading frame 10 |
| C1RL | complement component 1, r subcomponent-like |
| C5 | complement component 5 |
| C6ORF48 | chromosome 6 open reading frame 48 |
| CALCOCO1 | calcium binding and coiled-coil domain 1 |
| CAMLG | calcium modulating ligand |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase |
| CDK5RAP3 | CDK5 regulatory subunit associated protein 3 |
| CFB | complement factor B |
| CIDEB | cell death-inducing DFFA-like effector b |
| CSNK2A2 | casein kinase 2, alpha prime polypeptide |
| CST1 | cystatin SN |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 |
| DST | dystonin |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 |
| EIF4B | eukaryotic translation initiation factor 4B |
| EPS8 | epidermal growth factor receptor pathway substrate 8 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| F12 | coagulation factor XII (Hageman factor) |
| FAM63A | family with sequence similarity 63, member A |
| FAXDC2 | fatty acid hydroxylase domain containing 2 |
| FGG | fibrinogen gamma chain |
| FMO5 | flavin containing monooxygenase 5 |
| FOLR1 | folate receptor 1 (adult) |
| FOXN3 | forkhead box N3 |
| FOXO4 | forkhead box O4 |
| GAS6 | growth arrest-specific 6 |
| GDPD5 | glycerophosphodiester phosphodiesterase domain containing 5 |
| GLS | glutaminase |
| GOLGA8A | golgin A8 family, member A |
| GOLGA8B | golgin A8 family, member B |
| GOLGA8H | golgin A8 family, member H |
| GRN | granulin |
| GSDMB | gasdermin B |
| HDAC6 | histone deacetylase 6 |
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) |
| HP | haptoglobin |
| HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11 |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IGFBP1 | insulin-like growth factor binding protein 1 |
| IRS2 | insulin receptor substrate 2 |
| ITIH3 | inter-alpha-trypsin inhibitor heavy chain 3 |
| KLHL24 | kelch-like family member 24 |
| LETMD1 | LETM1 domain containing 1 |
| LGALS8 | lectin, galactoside-binding, soluble, 8 |
| LINC00341 | long intergenic non-protein coding RNA 341 |
| LONP2 | lon peptidase 2, peroxisomal |
| LTBP3 | latent transforming growth factor beta binding protein 3 |
| MTSS1 | metastasis suppressor 1 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| NBR1 | neighbor of BRCA1 gene 1 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) |
| NPDC1 | neural proliferation, differentiation and control, 1 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase |
| PABPC3 | poly(A) binding protein, cytoplasmic 3 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) |
| PHYH | phytanoyl-CoA 2-hydroxylase |
| PLAC8 | placenta-specific 8 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| PRAME | preferentially expressed antigen in melanoma |
| PRKCA | protein kinase C, alpha |
| PYGL | phosphorylase, glycogen, liver |
| R3HDM2 | R3H domain containing 2 |
| RAB17 | RAB17, member RAS oncogene family |
| RAP1GAP | RAP1 GTPase activating protein |
| RBKS | ribokinase |
| RELN | reelin |
| RGN | regucalcin |
| RPL38 | ribosomal protein L38 |
| RPS11 | ribosomal protein S11 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 |
| SLC22A18 | solute carrier family 22, member 18 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 |
| SLC35E2B | solute carrier family 35, member E2B |
| SORBS2 | sorbin and SH3 domain containing 2 |
| SORBS3 | sorbin and SH3 domain containing 3 |
| SPATA20 | spermatogenesis associated 20 |
| SPSB3 | splA/ryanodine receptor domain and SOCS box containing 3 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 |
| ST6GAL1 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 |
| SULT1A1 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 |
| SULT1A2 | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2 |
| SULT2A1 | sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 |
| TF | transferrin |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TM7SF2 | transmembrane 7 superfamily member 2 |
| TMEM45A | transmembrane protein 45A |
| TPP1 | tripeptidyl peptidase I |
| TSC2 | tuberous sclerosis 2 |
| TSPAN31 | tetraspanin 31 |
| TWF2 | twinfilin actin binding protein 2 |
| TXNIP | thioredoxin interacting protein |
| UGT2B28 | UDP glucuronosyltransferase 2 family, polypeptide B28 |
| VTN | vitronectin |
| WDR45 | WD repeat domain 45 |
| WDTC1 | WD and tetratricopeptide repeats 1 |
| Symbol | Name |
|---|---|
| ADAM9 | ADAM metallopeptidase domain 9 |
| ADM | adrenomedullin |
| ANXA1 | annexin A1 |
| ANXA3 | annexin A3 |
| AREG | amphiregulin |
| ATAD2 | ATPase family, AAA domain containing 2 |
| ATF3 | activating transcription factor 3 |
| AURKA | aurora kinase A |
| BID | BH3 interacting domain death agonist |
| BIRC5 | baculoviral IAP repeat containing 5 |
| BRCA1 | breast cancer 1, early onset |
| BTG3 | BTG family, member 3 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase |
| CA2 | carbonic anhydrase II |
| CAV1 | caveolin 1, caveolae protein, 22kDa |
| CCNA2 | cyclin A2 |
| CD24 | CD24 molecule |
| CDC20 | cell division cycle 20 |
| CDC25A | cell division cycle 25A |
| CDC42 | cell division cycle 42 |
| CDC6 | cell division cycle 6 |
| CDCA4 | cell division cycle associated 4 |
| CDK1 | cyclin-dependent kinase 1 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 |
| CENPA | centromere protein A |
| CENPN | centromere protein N |
| CENPU | centromere protein U |
| CEP55 | centrosomal protein 55kDa |
| CETN2 | centrin, EF-hand protein, 2 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CLU | clusterin |
| COL1A1 | collagen, type I, alpha 1 |
| COL1A2 | collagen, type I, alpha 2 |
| COL3A1 | collagen, type III, alpha 1 |
| COL6A3 | collagen, type VI, alpha 3 |
| CPE | carboxypeptidase E |
| CSRP2 | cysteine and glycine-rich protein 2 |
| CSTA | cystatin A (stefin A) |
| CXCL10 | chemokine (C-X-C motif) ligand 10 |
| DBF4 | DBF4 zinc finger |
| DCN | decorin |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 |
| DONSON | downstream neighbor of SON |
| DPT | dermatopontin |
| DSCC1 | DNA replication and sister chromatid cohesion 1 |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| DYNLT1 | dynein, light chain, Tctex-type 1 |
| E2F8 | E2F transcription factor 8 |
| EAF2 | ELL associated factor 2 |
| ECT2 | epithelial cell transforming 2 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EREG | epiregulin |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit |
| EZR | ezrin |
| F3 | coagulation factor III (thromboplastin, tissue factor) |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) |
| FAM129A | family with sequence similarity 129, member A |
| FEN1 | flap structure-specific endonuclease 1 |
| FOSL1 | FOS-like antigen 1 |
| GAL | galanin/GMAP prepropeptide |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| GJA1 | gap junction protein, alpha 1, 43kDa |
| GLIPR1 | GLI pathogenesis-related 1 |
| GTSE1 | G-2 and S-phase expressed 1 |
| H2AFX | H2A histone family, member X |
| HAT1 | histone acetyltransferase 1 |
| HILPDA | hypoxia inducible lipid droplet-associated |
| HJURP | Holliday junction recognition protein |
| HMGB2 | high mobility group box 2 |
| HOPX | HOP homeobox |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IGL | immunoglobulin lambda locus |
| KIAA0101 | KIAA0101 |
| KIF11 | kinesin family member 11 |
| KIF15 | kinesin family member 15 |
| KIF20A | kinesin family member 20A |
| KIF4A | kinesin family member 4A |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| KRT19 | keratin 19, type I |
| KRT8 | keratin 8, type II |
| LRRC17 | leucine rich repeat containing 17 |
| LUM | lumican |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) |
| MAP7 | microtubule-associated protein 7 |
| MCAM | melanoma cell adhesion molecule |
| MCM10 | minichromosome maintenance complex component 10 |
| MCM4 | minichromosome maintenance complex component 4 |
| MCM6 | minichromosome maintenance complex component 6 |
| MELK | maternal embryonic leucine zipper kinase |
| MKI67 | marker of proliferation Ki-67 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYL9 | myosin, light chain 9, regulatory |
| NCAPG | non-SMC condensin I complex, subunit G |
| NCAPG2 | non-SMC condensin II complex, subunit G2 |
| NEK2 | NIMA-related kinase 2 |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| ODC1 | ornithine decarboxylase 1 |
| PAK1IP1 | PAK1 interacting protein 1 |
| PALLD | palladin, cytoskeletal associated protein |
| PBK | PDZ binding kinase |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| PEA15 | phosphoprotein enriched in astrocytes 15 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 |
| PHTF2 | putative homeodomain transcription factor 2 |
| PLK4 | polo-like kinase 4 |
| PNP | purine nucleoside phosphorylase |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
| POSTN | periostin, osteoblast specific factor |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C |
| PTHLH | parathyroid hormone-like hormone |
| PTN | pleiotrophin |
| RANBP1 | RAN binding protein 1 |
| RFC3 | replication factor C (activator 1) 3, 38kDa |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa |
| RRM1 | ribonucleotide reductase M1 |
| RRM2 | ribonucleotide reductase M2 |
| S100A4 | S100 calcium binding protein A4 |
| S100A6 | S100 calcium binding protein A6 |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SFN | stratifin |
| SHCBP1 | SHC SH2-domain binding protein 1 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase |
| SMC4 | structural maintenance of chromosomes 4 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) |
| SPARCL1 | SPARC-like 1 (hevin) |
| SPC25 | SPC25, NDC80 kinetochore complex component |
| STMN1 | stathmin 1 |
| TAGLN | transgelin |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 |
| TK1 | thymidine kinase 1, soluble |
| TMPO | thymopoietin |
| TOP2A | topoisomerase (DNA) II alpha 170kDa |
| TPX2 | TPX2, microtubule-associated |
| TRIP13 | thyroid hormone receptor interactor 13 |
| TUBA4A | tubulin, alpha 4a |
| TUBB2A | tubulin, beta 2A class IIa |
| TUBB3 | tubulin, beta 3 class III |
| TUBB4B | tubulin, beta 4B class IVb |
| TUBB6 | tubulin, beta 6 class V |
| TYMS | thymidylate synthetase |
| UBE2C | ubiquitin-conjugating enzyme E2C |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UFD1L | ubiquitin fusion degradation 1 like (yeast) |
| VRK1 | vaccinia related kinase 1 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) |
| ZWINT | ZW10 interacting kinetochore protein |
