BRD-K42918627_GSK-2126458_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

275 genes differentially expressed following the BRD-K42918627_GSK-2126458_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADGRE5 adhesion G protein-coupled receptor E5
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AGTPBP1 ATP/GTP binding protein 1
AHNAK2 AHNAK nucleoprotein 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
ANKRD36B ankyrin repeat domain 36B
ANXA4 annexin A4
APOD apolipoprotein D
AREG amphiregulin
ARG2 arginase 2
ASPN asporin
ASXL2 additional sex combs like transcriptional regulator 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALHM2 calcium homeostasis modulator 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMLG calcium modulating ligand
CAV2 caveolin 2
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CDC25B cell division cycle 25B
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CIRBP cold inducible RNA binding protein
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN8 claudin 8
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COLEC11 collectin sub-family member 11
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRABP1 cellular retinoic acid binding protein 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
DARS aspartyl-tRNA synthetase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEPTOR DEP domain containing MTOR-interacting protein
DIAPH2 diaphanous-related formin 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EIF3D eukaryotic translation initiation factor 3, subunit D
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA4 EPH receptor A4
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM49A family with sequence similarity 49, member A
FGF13 fibroblast growth factor 13
FHOD3 formin homology 2 domain containing 3
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FNTA farnesyltransferase, CAAX box, alpha
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD2 FXYD domain containing ion transport regulator 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRASP1 G protein-coupled receptor associated sorting protein 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSE1 Gse1 coiled-coil protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
H3F3B H3 histone, family 3B (H3.3B)
HECA headcase homolog (Drosophila)
HIST3H2A histone cluster 3, H2a
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGA2 high mobility group AT-hook 2
HMGN4 high mobility group nucleosomal binding domain 4
HOXD1 homeobox D1
IGBP1 immunoglobulin (CD79A) binding protein 1
IL7 interleukin 7
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
JAG1 jagged 1
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LARP6 La ribonucleoprotein domain family, member 6
LETMD1 LETM1 domain containing 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LMO3 LIM domain only 3 (rhombotin-like 2)
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGP matrix Gla protein
MOXD1 monooxygenase, DBH-like 1
MTMR11 myotubularin related protein 11
MXRA7 matrix-remodelling associated 7
N4BP2L1 NEDD4 binding protein 2-like 1
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NINL ninein-like
NMRK1 nicotinamide riboside kinase 1
NOV nephroblastoma overexpressed
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OSBPL3 oxysterol binding protein-like 3
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4B phosphodiesterase 4B, cAMP-specific
PDE9A phosphodiesterase 9A
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PERP PERP, TP53 apoptosis effector
PHYH phytanoyl-CoA 2-hydroxylase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PNRC1 proline-rich nuclear receptor coactivator 1
PPAP2C phosphatidic acid phosphatase type 2C
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB31 RAB31, member RAS oncogene family
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3YL1 SH3 and SYLF domain containing 1
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SRSF7 serine/arginine-rich splicing factor 7
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
ST18 suppression of tumorigenicity 18, zinc finger
STEAP1 six transmembrane epithelial antigen of the prostate 1
STON1 stonin 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TRIB2 tribbles pseudokinase 2
UBE2B ubiquitin-conjugating enzyme E2B
VAT1 vesicle amine transport 1
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZNF277 zinc finger protein 277
ZNF292 zinc finger protein 292

decreased expression

Symbol Name
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ASPH aspartate beta-hydroxylase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCND3 cyclin D3
CDC6 cell division cycle 6
CLU clusterin
COL5A1 collagen, type V, alpha 1
CYB5A cytochrome b5 type A (microsomal)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ELAVL1 ELAV like RNA binding protein 1
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FKBP14 FK506 binding protein 14, 22 kDa
GALE UDP-galactose-4-epimerase
GBP1 guanylate binding protein 1, interferon-inducible
GCLM glutamate-cysteine ligase, modifier subunit
GINS2 GINS complex subunit 2 (Psf2 homolog)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTT1 glutathione S-transferase theta 1
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IARS isoleucyl-tRNA synthetase
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
KIAA0101 KIAA0101
KIAA0485 uncharacterized LOC57235
LRRC59 leucine rich repeat containing 59
LYZ lysozyme
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MSMO1 methylsterol monooxygenase 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NSF N-ethylmaleimide-sensitive factor
NUP210 nucleoporin 210kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRDX1 peroxiredoxin 1
QPRT quinolinate phosphoribosyltransferase
RGS1 regulator of G-protein signaling 1
RPN2 ribophorin II
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SMCO4 single-pass membrane protein with coiled-coil domains 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SQLE squalene epoxidase
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP6 syntaxin binding protein 6 (amisyn)
TFF3 trefoil factor 3 (intestinal)
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMEM97 transmembrane protein 97
TRIM16 tripartite motif containing 16
TSPAN3 tetraspanin 3
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
Funding