BRD-K42918627_GSK-2126458_LNCAP_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

57 genes differentially expressed following the BRD-K42918627_GSK-2126458_LNCAP_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARID5B AT rich interactive domain 5B (MRF1-like)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CXCL6 chemokine (C-X-C motif) ligand 6
IGFBP1 insulin-like growth factor binding protein 1
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAOB monoamine oxidase B
MDFIC MyoD family inhibitor domain containing
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
NAV2 neuron navigator 2
NOTCH2NL notch 2 N-terminal like
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SOX4 SRY (sex determining region Y)-box 4
TGFBR3 transforming growth factor, beta receptor III
TMPRSS3 transmembrane protease, serine 3

decreased expression

Symbol Name
ADM adrenomedullin
ALCAM activated leukocyte cell adhesion molecule
AQP1 aquaporin 1 (Colton blood group)
CCNE2 cyclin E2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
DDIT4 DNA-damage-inducible transcript 4
GNAS GNAS complex locus
HBD hemoglobin, delta
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
IGFBP5 insulin-like growth factor binding protein 5
LIMCH1 LIM and calponin homology domains 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MALL mal, T-cell differentiation protein-like
MAT2A methionine adenosyltransferase II, alpha
PCDH9 protocadherin 9
PDLIM1 PDZ and LIM domain 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
S100P S100 calcium binding protein P
SNAP25 synaptosomal-associated protein, 25kDa
SPP1 secreted phosphoprotein 1
TSPYL5 TSPY-like 5
Funding