BRD-K42918627_GSK-2126458_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

221 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD36B ankyrin repeat domain 36B
APOD apolipoprotein D
AREG amphiregulin
ARHGAP32 Rho GTPase activating protein 32
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP9A ATPase, class II, type 9A
BAG6 BCL2-associated athanogene 6
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CAST calpastatin
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRISP3 cysteine-rich secretory protein 3
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHRS3 dehydrogenase/reductase (SDR family) member 3
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EPS8 epidermal growth factor receptor pathway substrate 8
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FAXDC2 fatty acid hydroxylase domain containing 2
FGFR1 fibroblast growth factor receptor 1
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXN3 forkhead box N3
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FXR1 fragile X mental retardation, autosomal homolog 1
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCC2 GRIP and coiled-coil domain containing 2
GCLC glutamate-cysteine ligase, catalytic subunit
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GPR137B G protein-coupled receptor 137B
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HES1 hes family bHLH transcription factor 1
HIST1H2BD histone cluster 1, H2bd
HIST3H2A histone cluster 3, H2a
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IER5 immediate early response 5
IGBP1 immunoglobulin (CD79A) binding protein 1
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
KYNU kynureninase
LAMB3 laminin, beta 3
LETMD1 LETM1 domain containing 1
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAST4 microtubule associated serine/threonine kinase family member 4
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYLIP myosin regulatory light chain interacting protein
NAP1L1 nucleosome assembly protein 1-like 1
NCK2 NCK adaptor protein 2
NDRG1 N-myc downstream regulated 1
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
OPTN optineurin
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCBP2 poly(rC) binding protein 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKCH protein kinase C, eta
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RB1CC1 RB1-inducible coiled-coil 1
RGS10 regulator of G-protein signaling 10
RND3 Rho family GTPase 3
RPL14 ribosomal protein L14
RSRP1 arginine/serine-rich protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SERINC1 serine incorporator 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC38A2 solute carrier family 38, member 2
SOCS2 suppressor of cytokine signaling 2
SORBS3 sorbin and SH3 domain containing 3
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SQSTM1 sequestosome 1
STX1A syntaxin 1A (brain)
SYNGR3 synaptogyrin 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AK4 adenylate kinase 4
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
B3GNT1
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
CAPN1 calpain 1, (mu/I) large subunit
CCNA2 cyclin A2
CCND3 cyclin D3
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
COL5A1 collagen, type V, alpha 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DCTPP1 dCTP pyrophosphatase 1
DLD dihydrolipoamide dehydrogenase
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EBP emopamil binding protein (sterol isomerase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
EREG epiregulin
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
HAL histidine ammonia-lyase
HAT1 histone acetyltransferase 1
HAUS7 HAUS augmin-like complex, subunit 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LMNB1 lamin B1
LMNB2 lamin B2
LUM lumican
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MRPL12 mitochondrial ribosomal protein L12
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PNP purine nucleoside phosphorylase
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
RAD51 RAD51 recombinase
RANBP1 RAN binding protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORD sorbitol dehydrogenase
SPC25 SPC25, NDC80 kinetochore complex component
SPDL1 spindle apparatus coiled-coil protein 1
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
THBS1 thrombospondin 1
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TRIP13 thyroid hormone receptor interactor 13
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VRK1 vaccinia related kinase 1
ZWINT ZW10 interacting kinetochore protein
Funding