BRD-K42918627_GSK-2126458_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

93 genes differentially expressed following the BRD-K42918627_GSK-2126458_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARID5B AT rich interactive domain 5B (MRF1-like)
BPHL biphenyl hydrolase-like (serine hydrolase)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCDC28A coiled-coil domain containing 28A
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
CRYAB crystallin, alpha B
DEFB1 defensin, beta 1
DYSF dysferlin
EMP3 epithelial membrane protein 3
ENPEP glutamyl aminopeptidase (aminopeptidase A)
GPX3 glutathione peroxidase 3
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HOXC10 homeobox C10
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
JCHAIN joining chain of multimeric IgA and IgM
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT14 keratin 14, type I
KYNU kynureninase
LASP1 LIM and SH3 protein 1
MAPT microtubule-associated protein tau
MGP matrix Gla protein
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH2NL notch 2 N-terminal like
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
OSBPL1A oxysterol binding protein-like 1A
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
S100A2 S100 calcium binding protein A2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VCAN versican
VNN1 vanin 1

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
C2CD2 C2 calcium-dependent domain containing 2
CCND1 cyclin D1
CDC25A cell division cycle 25A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CXCL13 chemokine (C-X-C motif) ligand 13
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ETV5 ets variant 5
FAM57A family with sequence similarity 57, member A
GATA6 GATA binding protein 6
GREM1 gremlin 1, DAN family BMP antagonist
JAG1 jagged 1
JMJD6 jumonji domain containing 6
MAT2A methionine adenosyltransferase II, alpha
MMP12 matrix metallopeptidase 12
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGDS prostaglandin D2 synthase 21kDa (brain)
REG3A regenerating islet-derived 3 alpha
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TMEM158 transmembrane protein 158 (gene/pseudogene)
Funding