BRD-K42918627_GSK-2126458_MDAMB231_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K42918627_GSK-2126458_MDAMB231_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAM10 ADAM metallopeptidase domain 10
AHNAK2 AHNAK nucleoprotein 2
APOLD1 apolipoprotein L domain containing 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ATP9A ATPase, class II, type 9A
BCL6 B-cell CLL/lymphoma 6
C1RL complement component 1, r subcomponent-like
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CD9 CD9 molecule
CFI complement factor I
DDR1 discoidin domain receptor tyrosine kinase 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ETFB electron-transfer-flavoprotein, beta polypeptide
F2R coagulation factor II (thrombin) receptor
FAM114A1 family with sequence similarity 114, member A1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FUCA1 fucosidase, alpha-L- 1, tissue
FYCO1 FYVE and coiled-coil domain containing 1
GAA glucosidase, alpha; acid
GBP2 guanylate binding protein 2, interferon-inducible
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
IFI6 interferon, alpha-inducible protein 6
KLHL24 kelch-like family member 24
LDLR low density lipoprotein receptor
LPAR1 lysophosphatidic acid receptor 1
MAGED2 melanoma antigen family D2
MMP1 matrix metallopeptidase 1
MSRB2 methionine sulfoxide reductase B2
NPIPB3 nuclear pore complex interacting protein family, member B3
PDGFC platelet derived growth factor C
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRDX2 peroxiredoxin 2
RALGDS ral guanine nucleotide dissociation stimulator
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SULF1 sulfatase 1
TGIF1 TGFB-induced factor homeobox 1
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSC22D3 TSC22 domain family, member 3
ZBTB10 zinc finger and BTB domain containing 10
ZNF217 zinc finger protein 217
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BOP1 block of proliferation 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CTPS1 CTP synthase 1
DBF4 DBF4 zinc finger
ELANE elastase, neutrophil expressed
ELF5 E74-like factor 5 (ets domain transcription factor)
FEN1 flap structure-specific endonuclease 1
H2BFS H2B histone family, member S (pseudogene)
HAT1 histone acetyltransferase 1
HSPH1 heat shock 105kDa/110kDa protein 1
KRT5 keratin 5, type II
LTF lactotransferrin
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
RFC3 replication factor C (activator 1) 3, 38kDa
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
SMC2 structural maintenance of chromosomes 2
TMPO thymopoietin
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
Funding