BRD-K42918627_GSK-2126458_MDAMB231_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K42918627_GSK-2126458_MDAMB231_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
BHLHE41 basic helix-loop-helix family, member e41
C14ORF132 chromosome 14 open reading frame 132
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25B cell division cycle 25B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
FAM107A family with sequence similarity 107, member A
FAM189A2 family with sequence similarity 189, member A2
FOSL2 FOS-like antigen 2
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GAB2 GRB2-associated binding protein 2
GOLGB1 golgin B1
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GRN granulin
GSN gelsolin
HBB hemoglobin, beta
HBP1 HMG-box transcription factor 1
HEXA hexosaminidase A (alpha polypeptide)
IDS iduronate 2-sulfatase
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IRS2 insulin receptor substrate 2
JMJD1C jumonji domain containing 1C
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LXN latexin
MAGED1 melanoma antigen family D1
MEIS1 Meis homeobox 1
MLPH melanophilin
MMP1 matrix metallopeptidase 1
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
MYRF myelin regulatory factor
NAV2 neuron navigator 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFRL platelet-derived growth factor receptor-like
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POSTN periostin, osteoblast specific factor
PRUNE2 prune homolog 2 (Drosophila)
RALGDS ral guanine nucleotide dissociation stimulator
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARCL1 SPARC-like 1 (hevin)
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNM synemin, intermediate filament protein
TACC2 transforming, acidic coiled-coil containing protein 2
TBX2 T-box 2
TJP2 tight junction protein 2
TMEM100 transmembrane protein 100
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
VAT1 vesicle amine transport 1
VWF von Willebrand factor
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASF1B anti-silencing function 1B histone chaperone
BIRC5 baculoviral IAP repeat containing 5
CCNA2 cyclin A2
CD200 CD200 molecule
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CENPU centromere protein U
CNN3 calponin 3, acidic
COPS3 COP9 signalosome subunit 3
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTPS1 CTP synthase 1
DHFR dihydrofolate reductase
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
FST follistatin
GAL galanin/GMAP prepropeptide
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
H2AFX H2A histone family, member X
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
HNRNPL heterogeneous nuclear ribonucleoprotein L
IL17RB interleukin 17 receptor B
KIAA0101 KIAA0101
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MMP9 matrix metallopeptidase 9
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYCBP MYC binding protein
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NELL2 NEL-like 2 (chicken)
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM3 nucleophosmin/nucleoplasmin 3
NPTX2 neuronal pentraxin II
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
PCNA proliferating cell nuclear antigen
PGAM1 phosphoglycerate mutase 1 (brain)
PHACTR2 phosphatase and actin regulator 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RANBP1 RAN binding protein 1
RCAN1 regulator of calcineurin 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RPL37A ribosomal protein L37a
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPP1 secreted phosphoprotein 1
SRM spermidine synthase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TK1 thymidine kinase 1, soluble
TMEM97 transmembrane protein 97
TMPO thymopoietin
TUBG1 tubulin, gamma 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZWINT ZW10 interacting kinetochore protein
Funding