| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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245 genes differentially expressed following the BRD-K42918627_GSK-2126458_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ADGRE5 | adhesion G protein-coupled receptor E5 |
| AIM1 | absent in melanoma 1 |
| ANXA1 | annexin A1 |
| ANXA3 | annexin A3 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 |
| BACE2 | beta-site APP-cleaving enzyme 2 |
| BTG1 | B-cell translocation gene 1, anti-proliferative |
| BTG2 | BTG family, member 2 |
| CAV1 | caveolin 1, caveolae protein, 22kDa |
| CBLB | Cbl proto-oncogene B, E3 ubiquitin protein ligase |
| CCDC28A | coiled-coil domain containing 28A |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) |
| CDK19 | cyclin-dependent kinase 19 |
| CDK7 | cyclin-dependent kinase 7 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) |
| CLDN10 | claudin 10 |
| CST1 | cystatin SN |
| CTSL | cathepsin L |
| CTSS | cathepsin S |
| CYTH1 | cytohesin 1 |
| DAPK1 | death-associated protein kinase 1 |
| DARS | aspartyl-tRNA synthetase |
| DENND1B | DENN/MADD domain containing 1B |
| DUSP4 | dual specificity phosphatase 4 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 |
| EIF3D | eukaryotic translation initiation factor 3, subunit D |
| ERO1L | ERO1-like (S. cerevisiae) |
| FOXD1 | forkhead box D1 |
| FOXO3 | forkhead box O3 |
| FZD5 | frizzled class receptor 5 |
| GDF15 | growth differentiation factor 15 |
| GFOD1 | glucose-fructose oxidoreductase domain containing 1 |
| GLRX | glutaredoxin (thioltransferase) |
| GPR137B | G protein-coupled receptor 137B |
| HBP1 | HMG-box transcription factor 1 |
| HECA | headcase homolog (Drosophila) |
| HLA-E | major histocompatibility complex, class I, E |
| HMOX1 | heme oxygenase 1 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein |
| IDS | iduronate 2-sulfatase |
| IGBP1 | immunoglobulin (CD79A) binding protein 1 |
| IL32 | interleukin 32 |
| ITGA6 | integrin, alpha 6 |
| JUN | jun proto-oncogene |
| KDM3A | lysine (K)-specific demethylase 3A |
| KIAA0430 | KIAA0430 |
| KLF2 | Kruppel-like factor 2 |
| KLF6 | Kruppel-like factor 6 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) |
| KLHL24 | kelch-like family member 24 |
| KYNU | kynureninase |
| LAMP2 | lysosomal-associated membrane protein 2 |
| LCN2 | lipocalin 2 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 |
| LXN | latexin |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta |
| MGLL | monoglyceride lipase |
| MLPH | melanophilin |
| MTUS1 | microtubule associated tumor suppressor 1 |
| MVP | major vault protein |
| MXI1 | MAX interactor 1, dimerization protein |
| NCK2 | NCK adaptor protein 2 |
| NMI | N-myc (and STAT) interactor |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 |
| NRIP1 | nuclear receptor interacting protein 1 |
| NUCB2 | nucleobindin 2 |
| OPTN | optineurin |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 |
| PIK3IP1 | phosphoinositide-3-kinase interacting protein 1 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 |
| PLIN2 | perilipin 2 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa |
| PRAME | preferentially expressed antigen in melanoma |
| PSMB8 | proteasome (prosome, macropain) subunit, beta type, 8 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 |
| PTX3 | pentraxin 3, long |
| QPCT | glutaminyl-peptide cyclotransferase |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) |
| RAP1GAP | RAP1 GTPase activating protein |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) |
| RHOBTB3 | Rho-related BTB domain containing 3 |
| RIOK3 | RIO kinase 3 |
| RND3 | Rho family GTPase 3 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 |
| SLC2A10 | solute carrier family 2 (facilitated glucose transporter), member 10 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 |
| SMAD3 | SMAD family member 3 |
| SP140L | SP140 nuclear body protein-like |
| SPTLC2 | serine palmitoyltransferase, long chain base subunit 2 |
| SRGN | serglycin |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced |
| STC1 | stanniocalcin 1 |
| TBC1D9 | TBC1 domain family, member 9 (with GRAM domain) |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| TGIF1 | TGFB-induced factor homeobox 1 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase |
| TNIP1 | TNFAIP3 interacting protein 1 |
| TOM1L1 | target of myb1 (chicken)-like 1 |
| TPBG | trophoblast glycoprotein |
| TRIM2 | tripartite motif containing 2 |
| TSPAN1 | tetraspanin 1 |
| VPS28 | vacuolar protein sorting 28 homolog (S. cerevisiae) |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| XIST | X inactive specific transcript (non-protein coding) |
| YPEL5 | yippee-like 5 (Drosophila) |
| Symbol | Name |
|---|---|
| ABAT | 4-aminobutyrate aminotransferase |
| ACAT1 | acetyl-CoA acetyltransferase 1 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide |
| ADIRF | adipogenesis regulatory factor |
| ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ASPN | asporin |
| ASS1 | argininosuccinate synthase 1 |
| ATP6V0E2 | ATPase, H+ transporting V0 subunit e2 |
| BCHE | butyrylcholinesterase |
| BIRC5 | baculoviral IAP repeat containing 5 |
| C1QBP | complement component 1, q subcomponent binding protein |
| C3 | complement component 3 |
| CCL19 | chemokine (C-C motif) ligand 19 |
| CCNA2 | cyclin A2 |
| CCND2 | cyclin D2 |
| CDC25A | cell division cycle 25A |
| CDC42 | cell division cycle 42 |
| CDC7 | cell division cycle 7 |
| CDK1 | cyclin-dependent kinase 1 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase |
| CKS2 | CDC28 protein kinase regulatory subunit 2 |
| CLU | clusterin |
| COL14A1 | collagen, type XIV, alpha 1 |
| CRISPLD2 | cysteine-rich secretory protein LCCL domain containing 2 |
| CTSH | cathepsin H |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 |
| CYCS | cytochrome c, somatic |
| DCN | decorin |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 |
| DHCR24 | 24-dehydrocholesterol reductase |
| DHCR7 | 7-dehydrocholesterol reductase |
| DPT | dermatopontin |
| DTL | denticleless E3 ubiquitin protein ligase homolog (Drosophila) |
| EBP | emopamil binding protein (sterol isomerase) |
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| EFS | embryonal Fyn-associated substrate |
| EIF5A | eukaryotic translation initiation factor 5A |
| FASN | fatty acid synthase |
| FBLN1 | fibulin 1 |
| FCER1A | Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide |
| FEN1 | flap structure-specific endonuclease 1 |
| FH | fumarate hydratase |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) |
| H2AFX | H2A histone family, member X |
| HIGD1A | HIG1 hypoxia inducible domain family, member 1A |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 |
| HSPA1A | heat shock 70kDa protein 1A |
| HSPE1 | heat shock 10kDa protein 1 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 |
| ICMT | isoprenylcysteine carboxyl methyltransferase |
| IGHD | immunoglobulin heavy constant delta |
| IGHM | immunoglobulin heavy constant mu |
| IRF4 | interferon regulatory factor 4 |
| ITGB1BP1 | integrin beta 1 binding protein 1 |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KIAA0101 | KIAA0101 |
| KRT14 | keratin 14, type I |
| KRT15 | keratin 15, type I |
| KRT5 | keratin 5, type II |
| LIMCH1 | LIM and calponin homology domains 1 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| LUM | lumican |
| MCM4 | minichromosome maintenance complex component 4 |
| MELK | maternal embryonic leucine zipper kinase |
| MFAP4 | microfibrillar-associated protein 4 |
| MLEC | malectin |
| MPZL1 | myelin protein zero-like 1 |
| MTA1 | metastasis associated 1 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 |
| MYCBP | MYC binding protein |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) |
| NFIB | nuclear factor I/B |
| NME1 | NME/NM23 nucleoside diphosphate kinase 1 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 |
| NOP56 | NOP56 ribonucleoprotein |
| NPTX2 | neuronal pentraxin II |
| NUSAP1 | nucleolar and spindle associated protein 1 |
| NVL | nuclear VCP-like |
| PARP1 | poly (ADP-ribose) polymerase 1 |
| PCNA | proliferating cell nuclear antigen |
| PDE10A | phosphodiesterase 10A |
| PGRMC1 | progesterone receptor membrane component 1 |
| PHGDH | phosphoglycerate dehydrogenase |
| PKM | pyruvate kinase, muscle |
| PLN | phospholamban |
| PNP | purine nucleoside phosphorylase |
| PPIC | peptidylprolyl isomerase C (cyclophilin C) |
| PPIF | peptidylprolyl isomerase F |
| PRKAR2B | protein kinase, cAMP-dependent, regulatory, type II, beta |
| PRMT1 | protein arginine methyltransferase 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTGIS | prostaglandin I2 (prostacyclin) synthase |
| PYCR1 | pyrroline-5-carboxylate reductase 1 |
| RANBP1 | RAN binding protein 1 |
| RECK | reversion-inducing-cysteine-rich protein with kazal motifs |
| RFC4 | replication factor C (activator 1) 4, 37kDa |
| RGS13 | regulator of G-protein signaling 13 |
| RGS5 | regulator of G-protein signaling 5 |
| RRM2 | ribonucleotide reductase M2 |
| RTN1 | reticulon 1 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SDF2L1 | stromal cell-derived factor 2-like 1 |
| SLBP | stem-loop binding protein |
| SMC4 | structural maintenance of chromosomes 4 |
| SORBS1 | sorbin and SH3 domain containing 1 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 |
| SPON1 | spondin 1, extracellular matrix protein |
| SRM | spermidine synthase |
| ST7 | suppression of tumorigenicity 7 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| TCF4 | transcription factor 4 |
| TCL1A | T-cell leukemia/lymphoma 1A |
| TFAP2B | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) |
| TMEM97 | transmembrane protein 97 |
| TMPO | thymopoietin |
| TPSAB1 | tryptase alpha/beta 1 |
| TPSB2 | tryptase beta 2 (gene/pseudogene) |
| TYMS | thymidylate synthetase |
| UBE2S | ubiquitin-conjugating enzyme E2S |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) |
| WDR61 | WD repeat domain 61 |
| ZWINT | ZW10 interacting kinetochore protein |
