BRD-K43245338_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K43245338_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANK2 ankyrin 2, neuronal
ANXA3 annexin A3
ANXA5 annexin A5
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
BASP1 brain abundant, membrane attached signal protein 1
BICC1 BicC family RNA binding protein 1
BST2 bone marrow stromal cell antigen 2
C2CD2 C2 calcium-dependent domain containing 2
C5AR1 complement component 5a receptor 1
CCNE2 cyclin E2
CCPG1 cell cycle progression 1
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL5A2 collagen, type V, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSS cathepsin S
DMXL2 Dmx-like 2
EGR3 early growth response 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETV1 ets variant 1
F13A1 coagulation factor XIII, A1 polypeptide
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FBLN1 fibulin 1
FBP1 fructose-1,6-bisphosphatase 1
FBXL5 F-box and leucine-rich repeat protein 5
FGL2 fibrinogen-like 2
GSN gelsolin
HBD hemoglobin, delta
HEG1 heart development protein with EGF-like domains 1
HSPB8 heat shock 22kDa protein 8
INTS3 integrator complex subunit 3
JAG1 jagged 1
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LY75 lymphocyte antigen 75
MEIS1 Meis homeobox 1
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MMP7 matrix metallopeptidase 7
NBN nibrin
NR2F2 nuclear receptor subfamily 2, group F, member 2
OGFRL1 opioid growth factor receptor-like 1
PBX1 pre-B-cell leukemia homeobox 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
QKI QKI, KH domain containing, RNA binding
RBM47 RNA binding motif protein 47
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
S100P S100 calcium binding protein P
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
STAT1 signal transducer and activator of transcription 1, 91kDa
SVIL supervillin
TLE4 transducin-like enhancer of split 4
TLR4 toll-like receptor 4
TMX4 thioredoxin-related transmembrane protein 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TUSC3 tumor suppressor candidate 3
TYMP thymidine phosphorylase
WDR19 WD repeat domain 19

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CDC42 cell division cycle 42
COL6A1 collagen, type VI, alpha 1
DNTT DNA nucleotidylexotransferase
EIF5A eukaryotic translation initiation factor 5A
ENO1 enolase 1, (alpha)
FCGBP Fc fragment of IgG binding protein
FKSG49 FKSG49
FST follistatin
GPM6B glycoprotein M6B
GUSBP3 glucuronidase, beta pseudogene 3
HP haptoglobin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IPO13 importin 13
ITGA6 integrin, alpha 6
KLHL24 kelch-like family member 24
KRT5 keratin 5, type II
MT1E metallothionein 1E
MUC2 mucin 2, oligomeric mucus/gel-forming
NDRG2 NDRG family member 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OXA1L oxidase (cytochrome c) assembly 1-like
PAX5 paired box 5
PLK1 polo-like kinase 1
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PTPRO protein tyrosine phosphatase, receptor type, O
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STEAP1 six transmembrane epithelial antigen of the prostate 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
VEGFA vascular endothelial growth factor A
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF586 zinc finger protein 586
ZNF91 zinc finger protein 91
Funding