BRD-K43389675_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K43389675_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT13 acyl-CoA thioesterase 13
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADAMDEC1 ADAM-like, decysin 1
AEBP1 AE binding protein 1
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
CALD1 caldesmon 1
CD47 CD47 molecule
CD52 CD52 molecule
CETN2 centrin, EF-hand protein, 2
CKB creatine kinase, brain
CLDN3 claudin 3
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CREB1 cAMP responsive element binding protein 1
CTSZ cathepsin Z
DCN decorin
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DPYSL3 dihydropyrimidinase-like 3
EIF5A eukaryotic translation initiation factor 5A
ESRP1 epithelial splicing regulatory protein 1
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
GAS6 growth arrest-specific 6
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFT57 intraflagellar transport 57
ISG15 ISG15 ubiquitin-like modifier
LRRC15 leucine rich repeat containing 15
LTBP1 latent transforming growth factor beta binding protein 1
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
OLFM1 olfactomedin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRKCI protein kinase C, iota
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
STK39 serine threonine kinase 39
SULF1 sulfatase 1
TES testin LIM domain protein
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TNS1 tensin 1
TTC39A tetratricopeptide repeat domain 39A
TUBA1A tubulin, alpha 1a
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BEX1 brain expressed, X-linked 1
BLCAP bladder cancer associated protein
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
CCNF cyclin F
CCNL1 cyclin L1
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CRISP3 cysteine-rich secretory protein 3
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EIF4B eukaryotic translation initiation factor 4B
ETV5 ets variant 5
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FASTKD5 FAST kinase domains 5
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GRWD1 glutamate-rich WD repeat containing 1
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KIAA0907 KIAA0907
KLHL21 kelch-like family member 21
KRT7 keratin 7, type II
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MFSD10 major facilitator superfamily domain containing 10
MSX1 msh homeobox 1
MTF2 metal response element binding transcription factor 2
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMB neuromedin B
NOP56 NOP56 ribonucleoprotein
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PROM1 prominin 1
RAB5C RAB5C, member RAS oncogene family
RPL36 ribosomal protein L36
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SOBP sine oculis binding protein homolog (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNPO1 transportin 1
TSC22D2 TSC22 domain family, member 2
WDR6 WD repeat domain 6
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZNF22 zinc finger protein 22