BRD-K43389675_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

250 genes differentially expressed following the BRD-K43389675_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACPP acid phosphatase, prostate
ADGRF5 adhesion G protein-coupled receptor F5
AEBP1 AE binding protein 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BEX4 brain expressed, X-linked 4
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD47 CD47 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CFB complement factor B
CHGB chromogranin B
CIB2 calcium and integrin binding family member 2
CLC Charcot-Leyden crystal galectin
COL18A1 collagen, type XVIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CSTA cystatin A (stefin A)
CYBRD1 cytochrome b reductase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
EMP1 epithelial membrane protein 1
EXPH5 exophilin 5
FAM129A family with sequence similarity 129, member A
FASN fatty acid synthase
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FOXF1 forkhead box F1
FSTL1 follistatin-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXB2 homeobox B2
HPSE heparanase
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IL13RA1 interleukin 13 receptor, alpha 1
INSM1 insulinoma-associated 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LCK LCK proto-oncogene, Src family tyrosine kinase
LCN2 lipocalin 2
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MME membrane metallo-endopeptidase
MSMB microseminoprotein, beta-
MSN moesin
MX1 MX dynamin-like GTPase 1
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
NMU neuromedin U
NTS neurotensin
OLFM4 olfactomedin 4
PEA15 phosphoprotein enriched in astrocytes 15
PERP PERP, TP53 apoptosis effector
PGK1 phosphoglycerate kinase 1
PPAP2A phosphatidic acid phosphatase type 2A
PPL periplakin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDC2 syndecan 2
SEPP1 selenoprotein P, plasma, 1
SEPT10 septin 10
SH3BGR SH3 domain binding glutamate-rich protein
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRY4 sprouty homolog 4 (Drosophila)
STAP1 signal transducing adaptor family member 1
TARP TCR gamma alternate reading frame protein
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TRD T cell receptor delta locus
UGP2 UDP-glucose pyrophosphorylase 2
VAMP3 vesicle-associated membrane protein 3
VIM vimentin

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AURKA aurora kinase A
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
BMP2 bone morphogenetic protein 2
BRPF1 bromodomain and PHD finger containing, 1
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHD7 chromodomain helicase DNA binding protein 7
CHSY1 chondroitin sulfate synthase 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBF4 DBF4 zinc finger
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EHD1 EH-domain containing 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FBP1 fructose-1,6-bisphosphatase 1
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GOLGA8A golgin A8 family, member A
HEXIM1 hexamethylene bis-acetamide inducible 1
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KIAA0907 KIAA0907
KLF2 Kruppel-like factor 2
KRT7 keratin 7, type II
LINC00341 long intergenic non-protein coding RNA 341
LIPT1 lipoyltransferase 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MCL1 myeloid cell leukemia 1
MED13 mediator complex subunit 13
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA3 nuclear receptor coactivator 3
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NOTCH2NL notch 2 N-terminal like
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PCBP2 poly(rC) binding protein 2
PDGFA platelet-derived growth factor alpha polypeptide
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK1 polo-like kinase 1
PNN pinin, desmosome associated protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPAP2B phosphatidic acid phosphatase type 2B
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PTX3 pentraxin 3, long
RBM15 RNA binding motif protein 15
RGS4 regulator of G-protein signaling 4
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SCAF8 SR-related CTD-associated factor 8
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SET SET nuclear proto-oncogene
SETD5 SET domain containing 5
SIX1 SIX homeobox 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD3 SMAD family member 3
SNRPE small nuclear ribonucleoprotein polypeptide E
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK2 tousled-like kinase 2
TMEM243 transmembrane protein 243, mitochondrial
TOP2A topoisomerase (DNA) II alpha 170kDa
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TXLNA taxilin alpha
UBXN7 UBX domain protein 7
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZFC3H1 zinc finger, C3H1-type containing
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF443 zinc finger protein 443