BRD-K43389698_BMS-387032_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K43389698_BMS-387032_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ARHGAP6 Rho GTPase activating protein 6
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL10 B-cell CLL/lymphoma 10
BHLHE41 basic helix-loop-helix family, member e41
CAST calpastatin
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL4A5 collagen, type IV, alpha 5
CTBP2 C-terminal binding protein 2
DENND2D DENN/MADD domain containing 2D
DUSP4 dual specificity phosphatase 4
EHF ets homologous factor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
IFI44L interferon-induced protein 44-like
INPP1 inositol polyphosphate-1-phosphatase
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
LHX2 LIM homeobox 2
LRP10 low density lipoprotein receptor-related protein 10
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MMP7 matrix metallopeptidase 7
MYO6 myosin VI
NEBL nebulette
PBX3 pre-B-cell leukemia homeobox 3
PERP PERP, TP53 apoptosis effector
PHLDA2 pleckstrin homology-like domain, family A, member 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRNP prion protein
RAB38 RAB38, member RAS oncogene family
RNF11 ring finger protein 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
TACSTD2 tumor-associated calcium signal transducer 2
TFF1 trefoil factor 1
TMEM45A transmembrane protein 45A
TPBG trophoblast glycoprotein
TUFT1 tuftelin 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADI1 acireductone dioxygenase 1
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
APOA2 apolipoprotein A-II
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOH apolipoprotein H (beta-2-glycoprotein I)
BEX1 brain expressed, X-linked 1
C1S complement component 1, s subcomponent
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25B cell division cycle 25B
CDC6 cell division cycle 6
CDKN3 cyclin-dependent kinase inhibitor 3
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHEK2 checkpoint kinase 2
CRLF1 cytokine receptor-like factor 1
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
EBP emopamil binding protein (sterol isomerase)
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
GSTA1 glutathione S-transferase alpha 1
HACD2 3-hydroxyacyl-CoA dehydratase 2
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IL1R2 interleukin 1 receptor, type II
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0226L KIAA0226-like
LOC100505650 uncharacterized LOC100505650
MAN1A1 mannosidase, alpha, class 1A, member 1
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
NAMPT nicotinamide phosphoribosyltransferase
ORM1 orosomucoid 1
PAH phenylalanine hydroxylase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4B phosphodiesterase 4B, cAMP-specific
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
PSIP1 PC4 and SFRS1 interacting protein 1
RBP4 retinol binding protein 4, plasma
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
TAGLN transgelin
TCF4 transcription factor 4
TF transferrin
THY1 Thy-1 cell surface antigen
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN7 tetraspanin 7
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican
XBP1 X-box binding protein 1
Funding