BRD-K43389698_BMS-387032_HS578T_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-K43389698_BMS-387032_HS578T_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
ANO10 anoctamin 10
ANXA3 annexin A3
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BCHE butyrylcholinesterase
BLNK B-cell linker
CAV2 caveolin 2
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFH complement factor H
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FLRT2 fibronectin leucine rich transmembrane protein 2
G0S2 G0/G1 switch 2
GDE1 glycerophosphodiester phosphodiesterase 1
HLA-DOB major histocompatibility complex, class II, DO beta
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDS iduronate 2-sulfatase
IFITM3 interferon induced transmembrane protein 3
IL1R1 interleukin 1 receptor, type I
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAPTM4B lysosomal protein transmembrane 4 beta
LTBP3 latent transforming growth factor beta binding protein 3
LYRM1 LYR motif containing 1
MAPK13 mitogen-activated protein kinase 13
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
OSMR oncostatin M receptor
PDLIM1 PDZ and LIM domain 1
PLS3 plastin 3
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFTPB surfactant protein B
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
SLIT2 slit homolog 2 (Drosophila)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TGM2 transglutaminase 2
TMEM45A transmembrane protein 45A

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AHR aryl hydrocarbon receptor
APOLD1 apolipoprotein L domain containing 1
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATXN7 ataxin 7
BAMBI BMP and activin membrane-bound inhibitor
BCL10 B-cell CLL/lymphoma 10
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CBR3 carbonyl reductase 3
CCNG2 cyclin G2
CCNL1 cyclin L1
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
E2F3 E2F transcription factor 3
EDN1 endothelin 1
EFNA1 ephrin-A1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FASTKD5 FAST kinase domains 5
FBXL12 F-box and leucine-rich repeat protein 12
FBXL14 F-box and leucine-rich repeat protein 14
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXG1 forkhead box G1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GPM6B glycoprotein M6B
GTF2B general transcription factor IIB
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KBTBD2 kelch repeat and BTB (POZ) domain containing 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MRPS30 mitochondrial ribosomal protein S30
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXT1 nuclear transport factor 2-like export factor 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDZK1 PDZ domain containing 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PTRH2 peptidyl-tRNA hydrolase 2
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RNF19B ring finger protein 19B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAP30 Sin3A-associated protein, 30kDa
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SIRT1 sirtuin 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC38A2 solute carrier family 38, member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD7 SMAD family member 7
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRGN serglycin
SRSF7 serine/arginine-rich splicing factor 7
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM70 transmembrane protein 70
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
UGCG UDP-glucose ceramide glucosyltransferase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF12 zinc finger protein 12
ZNF217 zinc finger protein 217
Funding