BRD-K43389698_BMS-387032_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-K43389698_BMS-387032_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
BHLHE40 basic helix-loop-helix family, member e40
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CDC42 cell division cycle 42
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COPZ2 coatomer protein complex, subunit zeta 2
CPB1 carboxypeptidase B1 (tissue)
CSRP2 cysteine and glycine-rich protein 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYB5A cytochrome b5 type A (microsomal)
CYBB cytochrome b-245, beta polypeptide
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
G0S2 G0/G1 switch 2
GMPR guanosine monophosphate reductase
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HP haptoglobin
HRSP12 heat-responsive protein 12
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL13RA2 interleukin 13 receptor, alpha 2
INPP5F inositol polyphosphate-5-phosphatase F
IQCK IQ motif containing K
ISG15 ISG15 ubiquitin-like modifier
KIAA0226L KIAA0226-like
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LYN LYN proto-oncogene, Src family tyrosine kinase
METRN meteorin, glial cell differentiation regulator
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSN moesin
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHACTR1 phosphatase and actin regulator 1
PIR pirin (iron-binding nuclear protein)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLSCR3 phospholipid scramblase 3
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PSPH phosphoserine phosphatase
QDPR quinoid dihydropteridine reductase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
S100A1 S100 calcium binding protein A1
S100A11 S100 calcium binding protein A11
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SFTPC surfactant protein C
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC1 stanniocalcin 1
TCL1A T-cell leukemia/lymphoma 1A
TERT telomerase reverse transcriptase
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TSPAN1 tetraspanin 1
TTC3 tetratricopeptide repeat domain 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
APOD apolipoprotein D
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNOT7 CCR4-NOT transcription complex, subunit 7
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
GAS1 growth arrest-specific 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRB10 growth factor receptor-bound protein 10
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAT2A methionine adenosyltransferase II, alpha
MB myoglobin
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NOL11 nucleolar protein 11
NRN1 neuritin 1
PDZRN3 PDZ domain containing ring finger 3
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
RAB14 RAB14, member RAS oncogene family
RNPS1 RNA binding protein S1, serine-rich domain
RPL39L ribosomal protein L39-like
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX11 SRY (sex determining region Y)-box 11
TES testin LIM domain protein
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM251 transmembrane protein 251
TMEM97 transmembrane protein 97
TOB1 transducer of ERBB2, 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TPBG trophoblast glycoprotein
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
USP1 ubiquitin specific peptidase 1
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF185 zinc finger protein 185 (LIM domain)
Funding