BRD-K43389698_BMS-387032_MCF7_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K43389698_BMS-387032_MCF7_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADRB2 adrenoceptor beta 2, surface
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
BACE2 beta-site APP-cleaving enzyme 2
BEX1 brain expressed, X-linked 1
CCL20 chemokine (C-C motif) ligand 20
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COLEC12 collectin sub-family member 12
COX7C cytochrome c oxidase subunit VIIc
CRTAP cartilage associated protein
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXADR coxsackie virus and adenovirus receptor
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DKK3 dickkopf WNT signaling pathway inhibitor 3
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOXF1 forkhead box F1
FRY furry homolog (Drosophila)
FXYD5 FXYD domain containing ion transport regulator 5
GPNMB glycoprotein (transmembrane) nmb
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HIP1 huntingtin interacting protein 1
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IFRD2 interferon-related developmental regulator 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IL6ST interleukin 6 signal transducer
IL7R interleukin 7 receptor
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCTD12 potassium channel tetramerization domain containing 12
LDHB lactate dehydrogenase B
LRRC17 leucine rich repeat containing 17
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEIS2 Meis homeobox 2
METRN meteorin, glial cell differentiation regulator
MSN moesin
MSX1 msh homeobox 1
MXRA7 matrix-remodelling associated 7
NPDC1 neural proliferation, differentiation and control, 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRN1 neuritin 1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLAT plasminogen activator, tissue
PLVAP plasmalemma vesicle associated protein
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROSC proline synthetase co-transcribed homolog (bacterial)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGS5 regulator of G-protein signaling 5
RNF130 ring finger protein 130
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLIT2 slit homolog 2 (Drosophila)
SNAP25 synaptosomal-associated protein, 25kDa
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNGR3 synaptogyrin 3
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
THBS4 thrombospondin 4
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TMEM47 transmembrane protein 47
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN4 tetraspanin 4
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UQCR11 ubiquinol-cytochrome c reductase, complex III subunit XI
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
WNT5A wingless-type MMTV integration site family, member 5A
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACSL1 acyl-CoA synthetase long-chain family member 1
ADNP activity-dependent neuroprotector homeobox
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHERP calcium homeostasis endoplasmic reticulum protein
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP7 fatty acid binding protein 7, brain
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA3 GATA binding protein 3
GLOD4 glyoxalase domain containing 4
GREB1 growth regulation by estrogen in breast cancer 1
H2AFX H2A histone family, member X
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
KEAP1 kelch-like ECH-associated protein 1
KLHL21 kelch-like family member 21
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LTF lactotransferrin
LXN latexin
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
MELK maternal embryonic leucine zipper kinase
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MREG melanoregulin
MYB v-myb avian myeloblastosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NOL11 nucleolar protein 11
NPY1R neuropeptide Y receptor Y1
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAE1 ribonucleic acid export 1
RBM15 RNA binding motif protein 15
RET ret proto-oncogene
RNPS1 RNA binding protein S1, serine-rich domain
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACSTD2 tumor-associated calcium signal transducer 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
Funding