BRD-K43389698_BMS-387032_MCF7_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

190 genes differentially expressed following the BRD-K43389698_BMS-387032_MCF7_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACO1 aconitase 1, soluble
ADGRF5 adhesion G protein-coupled receptor F5
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMPD3 adenosine monophosphate deaminase 3
AQP1 aquaporin 1 (Colton blood group)
ARG1 arginase 1
BIN1 bridging integrator 1
BSG basigin (Ok blood group)
C7 complement component 7
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CSRP2 cysteine and glycine-rich protein 2
CXCL5 chemokine (C-X-C motif) ligand 5
DKK3 dickkopf WNT signaling pathway inhibitor 3
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
F3 coagulation factor III (thromboplastin, tissue factor)
FAM171A1 family with sequence similarity 171, member A1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FGFR1 fibroblast growth factor receptor 1
FKBP1A FK506 binding protein 1A, 12kDa
FOXF1 forkhead box F1
G0S2 G0/G1 switch 2
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLM1 golgi membrane protein 1
GPM6A glycoprotein M6A
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGKC immunoglobulin kappa constant
LHFP lipoma HMGIC fusion partner
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1B microtubule-associated protein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
NMU neuromedin U
OLFM4 olfactomedin 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCCA propionyl CoA carboxylase, alpha polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PFKM phosphofructokinase, muscle
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLS3 plastin 3
PPAP2C phosphatidic acid phosphatase type 2C
PRDX2 peroxiredoxin 2
PSPH phosphoserine phosphatase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7
SH3YL1 SH3 and SYLF domain containing 1
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TNNC1 troponin C type 1 (slow)
TPM2 tropomyosin 2 (beta)
TRIM22 tripartite motif containing 22
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2

decreased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHR aryl hydrocarbon receptor
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BEX4 brain expressed, X-linked 4
CCNE2 cyclin E2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK17 cyclin-dependent kinase 17
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CX3CR1 chemokine (C-X3-C motif) receptor 1
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGR2 early growth response 2
EIF5 eukaryotic translation initiation factor 5
ELF4 E74-like factor 4 (ets domain transcription factor)
ESR1 estrogen receptor 1
FAM208B family with sequence similarity 208, member B
FBXL14 F-box and leucine-rich repeat protein 14
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45B growth arrest and DNA-damage-inducible, beta
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GEMIN4 gem (nuclear organelle) associated protein 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
IRX5 iroquois homeobox 5
JADE2 jade family PHD finger 2
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KIF2A kinesin heavy chain member 2A
KRT14 keratin 14, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LYPD3 LY6/PLAUR domain containing 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NCOA2 nuclear receptor coactivator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLK2 polo-like kinase 2
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SCAF8 SR-related CTD-associated factor 8
SCGB2A2 secretoglobin, family 2A, member 2
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC38A2 solute carrier family 38, member 2
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SPEN spen family transcriptional repressor
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TRIB3 tribbles pseudokinase 3
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
VAV3 vav 3 guanine nucleotide exchange factor
WEE1 WEE1 G2 checkpoint kinase
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF217 zinc finger protein 217
Funding