BRD-K43978949_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K43978949_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
BASP1 brain abundant, membrane attached signal protein 1
CD52 CD52 molecule
CD58 CD58 molecule
CD9 CD9 molecule
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CST3 cystatin C
CXCL13 chemokine (C-X-C motif) ligand 13
CYBB cytochrome b-245, beta polypeptide
DEFA4 defensin, alpha 4, corticostatin
DUSP1 dual specificity phosphatase 1
EMP3 epithelial membrane protein 3
EREG epiregulin
FADS1 fatty acid desaturase 1
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GPX3 glutathione peroxidase 3
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMK granzyme K (granzyme 3; tryptase II)
IFITM3 interferon induced transmembrane protein 3
KLK5 kallikrein-related peptidase 5
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP7 microtubule-associated protein 7
MCTP1 multiple C2 domains, transmembrane 1
MNDA myeloid cell nuclear differentiation antigen
NR1H3 nuclear receptor subfamily 1, group H, member 3
PERP PERP, TP53 apoptosis effector
PLEK pleckstrin
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAD51C RAD51 paralog C
RGS2 regulator of G-protein signaling 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4

decreased expression

Symbol Name
AKAP13 A kinase (PRKA) anchor protein 13
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
BAG3 BCL2-associated athanogene 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CHSY1 chondroitin sulfate synthase 1
CLIC5 chloride intracellular channel 5
COL15A1 collagen, type XV, alpha 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPP4 dipeptidyl-peptidase 4
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5B eukaryotic translation initiation factor 5B
FCGBP Fc fragment of IgG binding protein
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
IFI44L interferon-induced protein 44-like
IL13RA2 interleukin 13 receptor, alpha 2
INHBB inhibin, beta B
LAMP3 lysosomal-associated membrane protein 3
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MGP matrix Gla protein
MMP11 matrix metallopeptidase 11
MOXD1 monooxygenase, DBH-like 1
MUC4 mucin 4, cell surface associated
MUC5B mucin 5B, oligomeric mucus/gel-forming
MX1 MX dynamin-like GTPase 1
NDNF neuron-derived neurotrophic factor
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PDZRN3 PDZ domain containing ring finger 3
PNISR PNN-interacting serine/arginine-rich protein
PODXL podocalyxin-like
PROM1 prominin 1
PRRC2C proline-rich coiled-coil 2C
RBMS1 RNA binding motif, single stranded interacting protein 1
RGCC regulator of cell cycle
RNF144A ring finger protein 144A
RPP38 ribonuclease P/MRP 38kDa subunit
SFTPB surfactant protein B
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SRRM2 serine/arginine repetitive matrix 2
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
STC1 stanniocalcin 1
TACSTD2 tumor-associated calcium signal transducer 2
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a