BRD-K44100512_KIN001-043_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-K44100512_KIN001-043_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL2A1 BCL2-related protein A1
BTG3 BTG family, member 3
CD52 CD52 molecule
CLIC5 chloride intracellular channel 5
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKC1 dyskeratosis congenita 1, dyskerin
ECM1 extracellular matrix protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP2 endoplasmic reticulum aminopeptidase 2
EREG epiregulin
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOSL1 FOS-like antigen 1
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GPI glucose-6-phosphate isomerase
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
KAZN kazrin, periplakin interacting protein
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LTF lactotransferrin
MAL mal, T-cell differentiation protein
MAP1B microtubule-associated protein 1B
MBP myelin basic protein
MCOLN1 mucolipin 1
MMP7 matrix metallopeptidase 7
MYH11 myosin, heavy chain 11, smooth muscle
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOV nephroblastoma overexpressed
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PGD phosphogluconate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAUR plasminogen activator, urokinase receptor
PPA1 pyrophosphatase (inorganic) 1
PPIF peptidylprolyl isomerase F
PSAT1 phosphoserine aminotransferase 1
PYCR1 pyrroline-5-carboxylate reductase 1
RAP1GAP RAP1 GTPase activating protein
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPIA ribose 5-phosphate isomerase A
RRAGD Ras-related GTP binding D
RRBP1 ribosome binding protein 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SRGN serglycin
TARS threonyl-tRNA synthetase
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNPO1 transportin 1
TREM1 triggering receptor expressed on myeloid cells 1
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
TTC3 tetratricopeptide repeat domain 3
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
ZDHHC6 zinc finger, DHHC-type containing 6

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACTC1 actin, alpha, cardiac muscle 1
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
ADGRG6 adhesion G protein-coupled receptor G6
ANXA9 annexin A9
ARHGAP29 Rho GTPase activating protein 29
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
CCNG2 cyclin G2
CD200 CD200 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A2 collagen, type IX, alpha 2
CRABP1 cellular retinoic acid binding protein 1
CSRP1 cysteine and glycine-rich protein 1
CSRP2 cysteine and glycine-rich protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
DAAM1 dishevelled associated activator of morphogenesis 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
EAPP E2F-associated phosphoprotein
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EFNB3 ephrin-B3
EPHA3 EPH receptor A3
FBN1 fibrillin 1
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FZD2 frizzled class receptor 2
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPR161 G protein-coupled receptor 161
H1FX H1 histone family, member X
H2AFX H2A histone family, member X
HBP1 HMG-box transcription factor 1
HIST1H4C histone cluster 1, H4c
HMGN3 high mobility group nucleosomal binding domain 3
HOXC10 homeobox C10
HSPA2 heat shock 70kDa protein 2
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM2 interferon induced transmembrane protein 2
IGF1R insulin-like growth factor 1 receptor
IGFBP7 insulin-like growth factor binding protein 7
INHBB inhibin, beta B
ITM2A integral membrane protein 2A
KLHDC2 kelch domain containing 2
LGALS1 lectin, galactoside-binding, soluble, 1
LHX2 LIM homeobox 2
LTBP1 latent transforming growth factor beta binding protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MB myoglobin
MBNL2 muscleblind-like splicing regulator 2
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MMP9 matrix metallopeptidase 9
MPDZ multiple PDZ domain protein
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NXN nucleoredoxin
OSR2 odd-skipped related transciption factor 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PEG10 paternally expressed 10
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PROM1 prominin 1
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PTCH1 patched 1
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SALL2 spalt-like transcription factor 2
SAMD4A sterile alpha motif domain containing 4A
SCPEP1 serine carboxypeptidase 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SNX10 sorting nexin 10
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
STON1 stonin 1
SYNGR3 synaptogyrin 3
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP2 TIMP metallopeptidase inhibitor 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM45A transmembrane protein 45A
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM1 tropomyosin 1 (alpha)
TUBA1A tubulin, alpha 1a
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
Funding