BRD-K44100512_KIN001-043_SKBR3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

181 genes differentially expressed following the BRD-K44100512_KIN001-043_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ADGRA3 adhesion G protein-coupled receptor A3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CALR calreticulin
CBR3 carbonyl reductase 3
CCP110 centriolar coiled coil protein 110kDa
CDC25B cell division cycle 25B
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CELF2 CUGBP, Elav-like family member 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKC1 dyskeratosis congenita 1, dyskerin
EMP3 epithelial membrane protein 3
ENO1 enolase 1, (alpha)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
ETV1 ets variant 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI44L interferon-induced protein 44-like
LIMCH1 LIM and calponin homology domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MOCOS molybdenum cofactor sulfurase
NAP1L1 nucleosome assembly protein 1-like 1
NOP16 NOP16 nucleolar protein
NPM3 nucleophosmin/nucleoplasmin 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PCDH9 protocadherin 9
PELO pelota homolog (Drosophila)
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PPIF peptidylprolyl isomerase F
PRR7 proline rich 7 (synaptic)
PSAT1 phosphoserine aminotransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PYCR1 pyrroline-5-carboxylate reductase 1
RHOBTB3 Rho-related BTB domain containing 3
SELL selectin L
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP1 secreted frizzled-related protein 1
SFTPB surfactant protein B
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TNIK TRAF2 and NCK interacting kinase
TSPYL5 TSPY-like 5
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCAS1 breast carcinoma amplified sequence 1
BCL6 B-cell CLL/lymphoma 6
BIK BCL2-interacting killer (apoptosis-inducing)
BLVRA biliverdin reductase A
BTG2 BTG family, member 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNG2 cyclin G2
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKB creatine kinase, brain
CNN1 calponin 1, basic, smooth muscle
CRIP1 cysteine-rich protein 1 (intestinal)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DES desmin
EFHD1 EF-hand domain family, member D1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GCHFR GTP cyclohydrolase I feedback regulator
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
HEBP2 heme binding protein 2
HECA headcase homolog (Drosophila)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HNMT histamine N-methyltransferase
HSBP1 heat shock factor binding protein 1
HSPB1 heat shock 27kDa protein 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGKV3-20 immunoglobulin kappa variable 3-20
IGKV4-1 immunoglobulin kappa variable 4-1
ILK integrin-linked kinase
INA internexin neuronal intermediate filament protein, alpha
INHBB inhibin, beta B
JCHAIN joining chain of multimeric IgA and IgM
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KRT4 keratin 4, type II
KRT5 keratin 5, type II
LIMA1 LIM domain and actin binding 1
LRP10 low density lipoprotein receptor-related protein 10
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
OBSL1 obscurin-like 1
OSR2 odd-skipped related transciption factor 2
PARVA parvin, alpha
PBX1 pre-B-cell leukemia homeobox 1
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PINK1 PTEN induced putative kinase 1
PLBD1 phospholipase B domain containing 1
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRKCD protein kinase C, delta
PYGL phosphorylase, glycogen, liver
RALB v-ral simian leukemia viral oncogene homolog B
RCAN1 regulator of calcineurin 1
RGCC regulator of cell cycle
RNF103 ring finger protein 103
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A12 S100 calcium binding protein A12
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SEPP1 selenoprotein P, plasma, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SKP1 S-phase kinase-associated protein 1
SLC38A2 solute carrier family 38, member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TGFB3 transforming growth factor, beta 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
YPEL5 yippee-like 5 (Drosophila)
Funding