BRD-K44100512_KIN001-043_SKBR3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K44100512_KIN001-043_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE40 basic helix-loop-helix family, member e40
BRCA1 breast cancer 1, early onset
BST2 bone marrow stromal cell antigen 2
CBS cystathionine-beta-synthase
CDC25B cell division cycle 25B
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CFI complement factor I
CTH cystathionine gamma-lyase
CYTIP cytohesin 1 interacting protein
DDIT4 DNA-damage-inducible transcript 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EREG epiregulin
EVI2B ecotropic viral integration site 2B
FADS1 fatty acid desaturase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
LARP1 La ribonucleoprotein domain family, member 1
LTF lactotransferrin
MET MET proto-oncogene, receptor tyrosine kinase
MID1IP1 MID1 interacting protein 1
MMP3 matrix metallopeptidase 3
NAMPT nicotinamide phosphoribosyltransferase
NKX2-1 NK2 homeobox 1
NPR3 natriuretic peptide receptor 3
NQO1 NAD(P)H dehydrogenase, quinone 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAX6 paired box 6
PCDH9 protocadherin 9
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFC platelet derived growth factor C
PDIA5 protein disulfide isomerase family A, member 5
PHGDH phosphoglycerate dehydrogenase
PPIF peptidylprolyl isomerase F
PRDX2 peroxiredoxin 2
PSAT1 phosphoserine aminotransferase 1
RHOBTB3 Rho-related BTB domain containing 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STC2 stanniocalcin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
VAV3 vav 3 guanine nucleotide exchange factor
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ARHGAP29 Rho GTPase activating protein 29
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BCAS1 breast carcinoma amplified sequence 1
BCL6 B-cell CLL/lymphoma 6
C3ORF14 chromosome 3 open reading frame 14
CAB39 calcium binding protein 39
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CAPN2 calpain 2, (m/II) large subunit
CAST calpastatin
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CD24 CD24 molecule
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CNN1 calponin 1, basic, smooth muscle
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CXCL9 chemokine (C-X-C motif) ligand 9
DES desmin
EFHD1 EF-hand domain family, member D1
EFNA1 ephrin-A1
EPAS1 endothelial PAS domain protein 1
ERBB3 erb-b2 receptor tyrosine kinase 3
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GRB7 growth factor receptor-bound protein 7
GSN gelsolin
H2AFV H2A histone family, member V
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPB1 heat shock 27kDa protein 1
IGL immunoglobulin lambda locus
ILK integrin-linked kinase
KIAA0355 KIAA0355
KLHDC2 kelch domain containing 2
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP9 matrix metallopeptidase 9
MT1X metallothionein 1X
MTUS1 microtubule associated tumor suppressor 1
MYH11 myosin, heavy chain 11, smooth muscle
NBEA neurobeachin
OAT ornithine aminotransferase
PBX1 pre-B-cell leukemia homeobox 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PGAP3 post-GPI attachment to proteins 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLN phospholamban
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RAB11A RAB11A, member RAS oncogene family
RAB31 RAB31, member RAS oncogene family
RALB v-ral simian leukemia viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RSRP1 arginine/serine-rich protein 1
S100A10 S100 calcium binding protein A10
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
SCGB2A2 secretoglobin, family 2A, member 2
SEPW1 selenoprotein W, 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC38A2 solute carrier family 38, member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SPDEF SAM pointed domain containing ETS transcription factor
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX7 syntaxin 7
TGFB3 transforming growth factor, beta 3
TM4SF4 transmembrane 4 L six family member 4
TMEM50A transmembrane protein 50A
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TWF1 twinfilin actin binding protein 1
WDTC1 WD and tetratricopeptide repeats 1
XBP1 X-box binding protein 1
Funding