BRD-K44227013_ponatinib_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-K44227013_ponatinib_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACKR3 atypical chemokine receptor 3
ACSF2 acyl-CoA synthetase family member 2
AGR2 anterior gradient 2
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CP ceruloplasmin (ferroxidase)
CREBL2 cAMP responsive element binding protein-like 2
CST3 cystatin C
CTSA cathepsin A
CTSH cathepsin H
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DIAPH2 diaphanous-related formin 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM13A family with sequence similarity 13, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FOXO4 forkhead box O4
GLRX glutaredoxin (thioltransferase)
GRN granulin
GSDMB gasdermin B
GSN gelsolin
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2C integral membrane protein 2C
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLHL24 kelch-like family member 24
LAMP2 lysosomal-associated membrane protein 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MGST3 microsomal glutathione S-transferase 3
MTSS1 metastasis suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NBPF10 neuroblastoma breakpoint family, member 10
NPC2 Niemann-Pick disease, type C2
NUPR1 nuclear protein, transcriptional regulator, 1
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PBLD phenazine biosynthesis-like protein domain containing
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PROM1 prominin 1
PROS1 protein S (alpha)
PRSS8 protease, serine, 8
PSAP prosaposin
PSPH phosphoserine phosphatase
QPRT quinolinate phosphoribosyltransferase
RAB13 RAB13, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
SCPEP1 serine carboxypeptidase 1
SEPP1 selenoprotein P, plasma, 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX4 SRY (sex determining region Y)-box 4
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TFEC transcription factor EC
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TPP1 tripeptidyl peptidase I
TSPAN6 tetraspanin 6
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ABLIM1 actin binding LIM protein 1
AEBP1 AE binding protein 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
C1QBP complement component 1, q subcomponent binding protein
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CEMIP cell migration inducing protein, hyaluronan binding
COL1A1 collagen, type I, alpha 1
CPE carboxypeptidase E
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTPS1 CTP synthase 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL8 chemokine (C-X-C motif) ligand 8
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMG1 EMG1 N1-specific pseudouridine methyltransferase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOSL1 FOS-like antigen 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
H2AFX H2A histone family, member X
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
JMJD6 jumonji domain containing 6
KIF20A kinesin family member 20A
LTF lactotransferrin
MCM4 minichromosome maintenance complex component 4
MCM6 minichromosome maintenance complex component 6
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PTRF polymerase I and transcript release factor
PUS7 pseudouridylate synthase 7 (putative)
RAN RAN, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RPL38 ribosomal protein L38
RPP40 ribonuclease P/MRP 40kDa subunit
RRM1 ribonucleotide reductase M1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRM spermidine synthase
SRSF2 serine/arginine-rich splicing factor 2
STC1 stanniocalcin 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TNC tenascin C
Funding