| Dataset | LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map) |
| Similar Terms | |
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125 genes differentially expressed following the BRD-K44227013_ponatinib_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| 1060P11.3 | killer cell immunoglobulin-like receptor, three domains, pseudogene |
| ACTB | actin, beta |
| AIM1 | absent in melanoma 1 |
| ALDH4A1 | aldehyde dehydrogenase 4 family, member A1 |
| AMDHD2 | amidohydrolase domain containing 2 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| CA2 | carbonic anhydrase II |
| CALD1 | caldesmon 1 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 |
| CCNG2 | cyclin G2 |
| CES2 | carboxylesterase 2 |
| CRTAP | cartilage associated protein |
| CSTA | cystatin A (stefin A) |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| DDIT4 | DNA-damage-inducible transcript 4 |
| DUSP1 | dual specificity phosphatase 1 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) |
| EPHA3 | EPH receptor A3 |
| FHL1 | four and a half LIM domains 1 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| GLS | glutaminase |
| GSN | gelsolin |
| GUSBP11 | glucuronidase, beta pseudogene 11 |
| HIST1H2AC | histone cluster 1, H2ac |
| HIST1H2BD | histone cluster 1, H2bd |
| HIST1H2BG | histone cluster 1, H2bg |
| IFI27 | interferon, alpha-inducible protein 27 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa |
| IGL | immunoglobulin lambda locus |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 |
| JCHAIN | joining chain of multimeric IgA and IgM |
| KRT14 | keratin 14, type I |
| LGALS4 | lectin, galactoside-binding, soluble, 4 |
| MARCH8 | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase |
| MCOLN1 | mucolipin 1 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 |
| NDRG2 | NDRG family member 2 |
| OLFM4 | olfactomedin 4 |
| PBLD | phenazine biosynthesis-like protein domain containing |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) |
| PHGDH | phosphoglycerate dehydrogenase |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) |
| PLCB4 | phospholipase C, beta 4 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 |
| PRUNE2 | prune homolog 2 (Drosophila) |
| PSAT1 | phosphoserine aminotransferase 1 |
| RAB40B | RAB40B, member RAS oncogene family |
| REG1A | regenerating islet-derived 1 alpha |
| RHOB | ras homolog family member B |
| RPL39L | ribosomal protein L39-like |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 |
| RRAGC | Ras-related GTP binding C |
| RTN1 | reticulon 1 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) |
| SPRR1A | small proline-rich protein 1A |
| SPRR1B | small proline-rich protein 1B |
| SPRR2B | small proline-rich protein 2B |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) |
| TSC22D3 | TSC22 domain family, member 3 |
| TXNIP | thioredoxin interacting protein |
| VDAC1 | voltage-dependent anion channel 1 |
| WWP1 | WW domain containing E3 ubiquitin protein ligase 1 |
| Symbol | Name |
|---|---|
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
| AKR1C1 | aldo-keto reductase family 1, member C1 |
| AKR1C2 | aldo-keto reductase family 1, member C2 |
| ALDOA | aldolase A, fructose-bisphosphate |
| APOA1 | apolipoprotein A-I |
| APOB | apolipoprotein B |
| APOE | apolipoprotein E |
| ATF3 | activating transcription factor 3 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
| BTG3 | BTG family, member 3 |
| C8ORF4 | chromosome 8 open reading frame 4 |
| CCND2 | cyclin D2 |
| COL3A1 | collagen, type III, alpha 1 |
| COL6A3 | collagen, type VI, alpha 3 |
| COPS4 | COP9 signalosome subunit 4 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| EMG1 | EMG1 N1-specific pseudouridine methyltransferase |
| EPCAM | epithelial cell adhesion molecule |
| FBXL12 | F-box and leucine-rich repeat protein 12 |
| FGA | fibrinogen alpha chain |
| FGG | fibrinogen gamma chain |
| FILIP1L | filamin A interacting protein 1-like |
| GPM6B | glycoprotein M6B |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A |
| GTF2A2 | general transcription factor IIA, 2, 12kDa |
| HAL | histidine ammonia-lyase |
| HEPH | hephaestin |
| HIC2 | hypermethylated in cancer 2 |
| HOPX | HOP homeobox |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) |
| ITM2A | integral membrane protein 2A |
| KLF10 | Kruppel-like factor 10 |
| KRT19 | keratin 19, type I |
| KRT7 | keratin 7, type II |
| LAPTM5 | lysosomal protein transmembrane 5 |
| LBH | limb bud and heart development |
| LIF | leukemia inhibitory factor |
| LIMS1 | LIM and senescent cell antigen-like domains 1 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F |
| MAPKAPK5 | mitogen-activated protein kinase-activated protein kinase 5 |
| MYBPC1 | myosin binding protein C, slow type |
| NDUFC2 | NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa |
| NLRP2 | NLR family, pyrin domain containing 2 |
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide |
| POSTN | periostin, osteoblast specific factor |
| RGCC | regulator of cell cycle |
| S100A6 | S100 calcium binding protein A6 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 |
| SPARCL1 | SPARC-like 1 (hevin) |
| SRGN | serglycin |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMSB15A | thymosin beta 15a |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 |
| TOX3 | TOX high mobility group box family member 3 |
