BRD-K44781077_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K44781077_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
BCHE butyrylcholinesterase
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CCL5 chemokine (C-C motif) ligand 5
CD40 CD40 molecule, TNF receptor superfamily member 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHMP4A charged multivesicular body protein 4A
CLGN calmegin
COL9A2 collagen, type IX, alpha 2
CPE carboxypeptidase E
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FAM69A family with sequence similarity 69, member A
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GRB7 growth factor receptor-bound protein 7
GREM1 gremlin 1, DAN family BMP antagonist
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IDO1 indoleamine 2,3-dioxygenase 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
LTB lymphotoxin beta (TNF superfamily, member 3)
LYZ lysozyme
MATN2 matrilin 2
MMP10 matrix metallopeptidase 10
NUCB2 nucleobindin 2
NVL nuclear VCP-like
OSBPL10 oxysterol binding protein-like 10
PID1 phosphotyrosine interaction domain containing 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2A phosphatidic acid phosphatase type 2A
PPAP2B phosphatidic acid phosphatase type 2B
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRUNE2 prune homolog 2 (Drosophila)
RBM34 RNA binding motif protein 34
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX7 sorting nexin 7
SOCS2 suppressor of cytokine signaling 2
SRP72 signal recognition particle 72kDa
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TSPAN12 tetraspanin 12
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
APLP2 amyloid beta (A4) precursor-like protein 2
C8ORF4 chromosome 8 open reading frame 4
CD59 CD59 molecule, complement regulatory protein
CST3 cystatin C
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAR2 fatty acyl CoA reductase 2
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FMO5 flavin containing monooxygenase 5
FZD7 frizzled class receptor 7
GSTA4 glutathione S-transferase alpha 4
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IRS2 insulin receptor substrate 2
KRT6B keratin 6B, type II
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP2 microfibrillar-associated protein 2
NAMPT nicotinamide phosphoribosyltransferase
PI3 peptidase inhibitor 3, skin-derived
PLTP phospholipid transfer protein
RPS4Y1 ribosomal protein S4, Y-linked 1
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
SELL selectin L
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TAGLN2 transgelin 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican