BRD-K44849676_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

95 genes differentially expressed following the BRD-K44849676_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C5AR1 complement component 5a receptor 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CD163 CD163 molecule
CD58 CD58 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CLU clusterin
CPVL carboxypeptidase, vitellogenic-like
CST3 cystatin C
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
FADS2 fatty acid desaturase 2
FOLR1 folate receptor 1 (adult)
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
INSIG1 insulin induced gene 1
INSIG2 insulin induced gene 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LPAR2 lysophosphatidic acid receptor 2
MAT2A methionine adenosyltransferase II, alpha
MCOLN1 mucolipin 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
PIR pirin (iron-binding nuclear protein)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PROM1 prominin 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SATB1 SATB homeobox 1
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP4 TIMP metallopeptidase inhibitor 4
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5

decreased expression

Symbol Name
ACPP acid phosphatase, prostate
ACTN1 actinin, alpha 1
CA2 carbonic anhydrase II
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CX3CR1 chemokine (C-X3-C motif) receptor 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAIM Fas apoptotic inhibitory molecule
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ITPKB inositol-trisphosphate 3-kinase B
MBP myelin basic protein
MYOF myoferlin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PAPD7 PAP associated domain containing 7
PDZRN3 PDZ domain containing ring finger 3
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHF10 PHD finger protein 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN2 regulator of calcineurin 2
RGCC regulator of cell cycle
RIPK4 receptor-interacting serine-threonine kinase 4
SCGB2A1 secretoglobin, family 2A, member 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SHB Src homology 2 domain containing adaptor protein B
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TFPI2 tissue factor pathway inhibitor 2
TMPRSS2 transmembrane protease, serine 2
ZNF395 zinc finger protein 395
Funding