BRD-K45044657_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K45044657_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABLIM1 actin binding LIM protein 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
ANXA4 annexin A4
ATF3 activating transcription factor 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA1 cyclin A1
CCNG2 cyclin G2
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD58 CD58 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
CPA3 carboxypeptidase A3 (mast cell)
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
ECM1 extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FADS2 fatty acid desaturase 2
FILIP1L filamin A interacting protein 1-like
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL32 interleukin 32
ITGA6 integrin, alpha 6
KCNK1 potassium channel, two pore domain subfamily K, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT8 keratin 8, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MYH11 myosin, heavy chain 11, smooth muscle
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SFRP4 secreted frizzled-related protein 4
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPRED2 sprouty-related, EVH1 domain containing 2
SYNM synemin, intermediate filament protein
THBS2 thrombospondin 2
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TUBB2B tubulin, beta 2B class IIb
WFDC1 WAP four-disulfide core domain 1

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
C1S complement component 1, s subcomponent
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFB complement factor B
COPS7A COP9 signalosome subunit 7A
CXCL13 chemokine (C-X-C motif) ligand 13
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FKBP11 FK506 binding protein 11, 19 kDa
JADE2 jade family PHD finger 2
MRPS2 mitochondrial ribosomal protein S2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PI3 peptidase inhibitor 3, skin-derived
PTGES prostaglandin E synthase