BRD-K45205755_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

54 genes differentially expressed following the BRD-K45205755_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG3 BCL2-associated athanogene 3
BRD2 bromodomain containing 2
CD163 CD163 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
FOXO4 forkhead box O4
FYN FYN proto-oncogene, Src family tyrosine kinase
GCLC glutamate-cysteine ligase, catalytic subunit
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MT1M metallothionein 1M
NBPF10 neuroblastoma breakpoint family, member 10
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
CCND1 cyclin D1
CD8A CD8a molecule
CDK4 cyclin-dependent kinase 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
EIF5A eukaryotic translation initiation factor 5A
ENOPH1 enolase-phosphatase 1
FRZB frizzled-related protein
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
PEG3 paternally expressed 3
RAB2A RAB2A, member RAS oncogene family
RGS5 regulator of G-protein signaling 5
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SOX9 SRY (sex determining region Y)-box 9
TPD52 tumor protein D52
TSPAN8 tetraspanin 8
Funding