BRD-K45253154_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

133 genes differentially expressed following the BRD-K45253154_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
APOD apolipoprotein D
ARG2 arginase 2
BCHE butyrylcholinesterase
C1RL complement component 1, r subcomponent-like
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CBR3 carbonyl reductase 3
CFB complement factor B
CFD complement factor D (adipsin)
CHRDL1 chordin-like 1
COL9A2 collagen, type IX, alpha 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
EPN2 epsin 2
FADS1 fatty acid desaturase 1
FAM129A family with sequence similarity 129, member A
FSD1 fibronectin type III and SPRY domain containing 1
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA12A heat shock 70kDa protein 12A
HSPA2 heat shock 70kDa protein 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGSF3 immunoglobulin superfamily, member 3
ISG15 ISG15 ubiquitin-like modifier
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA1644 KIAA1644
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGALS8 lectin, galactoside-binding, soluble, 8
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOB monoamine oxidase B
MAP1B microtubule-associated protein 1B
MATN2 matrilin 2
MKNK1 MAP kinase interacting serine/threonine kinase 1
MT1M metallothionein 1M
MTSS1 metastasis suppressor 1
MX1 MX dynamin-like GTPase 1
NCAM1 neural cell adhesion molecule 1
NELL2 NEL-like 2 (chicken)
NKX3-1 NK3 homeobox 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSBPL10 oxysterol binding protein-like 10
PBK PDZ binding kinase
PDZRN3 PDZ domain containing ring finger 3
PGF placental growth factor
PGM1 phosphoglucomutase 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLIN2 perilipin 2
PNMA2 paraneoplastic Ma antigen 2
PON2 paraoxonase 2
PRKCA protein kinase C, alpha
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTK2 protein tyrosine kinase 2
PTN pleiotrophin
REEP1 receptor accessory protein 1
RIMS3 regulating synaptic membrane exocytosis 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN1 reticulon 1
RTN2 reticulon 2
SCCPDH saccharopine dehydrogenase (putative)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
STMN2 stathmin 2
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
SYNM synemin, intermediate filament protein
TFPI2 tissue factor pathway inhibitor 2
TGFBR3 transforming growth factor, beta receptor III
THSD7A thrombospondin, type I, domain containing 7A
TMSB15A thymosin beta 15a
TNC tenascin C
TRIM2 tripartite motif containing 2
USP18 ubiquitin specific peptidase 18
VLDLR very low density lipoprotein receptor
XAF1 XIAP associated factor 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
AGR2 anterior gradient 2
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AREG amphiregulin
ASPN asporin
BAG1 BCL2-associated athanogene
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DPH2 DPH2 homolog (S. cerevisiae)
EPCAM epithelial cell adhesion molecule
EREG epiregulin
FKBP10 FK506 binding protein 10, 65 kDa
GCLC glutamate-cysteine ligase, catalytic subunit
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H2AC histone cluster 1, H2ac
ITGB1BP1 integrin beta 1 binding protein 1
KCTD12 potassium channel tetramerization domain containing 12
KIDINS220 kinase D-interacting substrate, 220kDa
LCN2 lipocalin 2
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METTL1 methyltransferase like 1
NUP98 nucleoporin 98kDa
POSTN periostin, osteoblast specific factor
PRKD3 protein kinase D3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TCF4 transcription factor 4
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TMC5 transmembrane channel-like 5
TSPAN8 tetraspanin 8
UBE2G2 ubiquitin-conjugating enzyme E2G 2
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WDR43 WD repeat domain 43
ZNF586 zinc finger protein 586
Funding